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Neural Antibodies | The Key to Precise Detection of Nerve Cell Markers
The development of neuronal and glial cells in the central nervous system
https://doi.org/10.3389/fcell.2021.754606
The nervous system formed by nerve cells is the core of the executive function of the brain. Different kinds of nerve cells play different physiological functions. Accurately distinguishing these nerve cells has important guiding significance for neuroscience research. Neural antibodies can specifically label and recognize specific molecules on nerve cells, helping researchers to accurately distinguish and identify different types of nerve cells, and further study their roles and interrelationships in the nervous system. Additionally, many neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), etc., are associated with damage or dysfunction of specific nerve cell types. By using neural antibodies, it is possible to monitor changes in these nerve cells, assess the progression of the disease, and provide patients with more accurate diagnosis and treatment. In addition, neural antibodies also have a wide range of applications in the fields of neural development, neural regeneration and neural drug research and development.
As the neuroscience-focused brand of ACROBiosystems, Aneuro offers a series of specialized neural antibodies designed for neuroscience research, characterized by high specificity, sensitivity, and stability. Rigorously validated, these antibodies can specifically bind to neural markers expressed in cerebral organoids. This contributes to a more comprehensive understanding and study of the biological properties, functions, and mechanisms of nerve cells in neurodegenerative diseases.
Product List
| Molecule | Cat. No. | Product Description | Application |
|---|---|---|---|
| GFAP | GFP-S453 | Polyclonal GFAP Antibody, Rabbit IgG | Specific binding with GFAP to identify astrocytes |
| NG2/Cspg4 | NG4-S455 | Polyclonal NG2/Cspg4 Antibody, Rabbit IgG | Specific binding with NG2 to identify oligodendrocyte progenitors |
| Olig2 | OL2-S456 | Polyclonal Olig2 Antibody, Rabbit IgG | Specific binding with Olig2 to identify oligodendrocytes |
| NeuN/Rbfox3 | NE3-S454 | Monoclonal NeuN/Rbfox3 Antibody, Mouse IgG1 | Specific binding with NeuN to identify mature neurons |
Verification Data
As verified by immunofluorescence, neural antibodies can specifically bind with markers in cerebral organoids.
Immunofluorescent staining (10X) of cerebral organoid-derived cells (Cat. No. CIPO-BWL001K) labeling NeuN (Red) with purified Monoclonal NeuN/Rbfox3 Antibody, Mouse IgG1 (Cat. No. NE3-S454) at 1:500 dilution. DAPI (blue) was used as nuclear counterstain.
Immunofluorescent staining (10X) of cerebral organoid-derived cells (Cat. No. CIPO-BWL001K) labeling GFAP (Red) with purified Polyclonal GFAP Antibody, Rabbit IgG (Cat. No. GFP-S453) at 1:200 dilution. DAPI (blue) was used as nuclear counterstain.
Immunofluorescent staining (10X) of cerebral organoid-derived cells (Cat. No. CIPO-BWL001K) labeling NG2 (Red) with purified Polyclonal NG2/Cspg4 Antibody, Rabbit IgG (Cat. No. NG4-S455) at 1:200 dilution. DAPI (blue) was used as nuclear counterstain.
Immunofluorescent staining (10X) of cerebral organoid-derived cells (Cat. No. CIPO-BWL001K) labeling Olig2 (Red) with purified Polyclonal Olig2 Antibody, Rabbit IgG (Cat. No. OL2-S456) at 1:200 dilution. DAPI (blue) was used as nuclear counterstain.
References
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- 2. Yokoo H, Nobusawa S, Takebayashi H, et al. Anti-human Olig2 antibody as a useful immunohistochemical marker of normal oligodendrocytes and gliomas[J]. The American journal of pathology, 2004, 164(5): 1717-1725. https://doi.org/10.1016/S0002-9440(10)63730-3
- 3. Zhao W, Dumanis S B, Tamboli I Y, et al. Human APOE genotype affects intraneuronal Aβ1–42 accumulation in a lentiviral gene transfer model[J]. Human molecular genetics, 2014, 23(5): 1365-1375. https://doi.org/10.1093/hmg/ddt525
- 4. Yu L, Chen C, Wang L F, et al. Neuroprotective effect of kaempferol glycosides against brain injury and neuroinflammation by inhibiting the activation of NF-κB and STAT3 in transient focal stroke[J]. PloS one, 2013, 8(2): e55839. https://doi.org/10.1371/journal.pone.0055839
- 5. Rigo Y R, Benvenutti R, Portela L V, et al. Neurogenic potential of NG2 in neurotrauma: a systematic review[J]. Neural Regeneration Research, 2024, 19(12): 2673-2683. https://doi.org/10.4103/NRR.NRR-D-23-01031
- 6. Englund C, Fink A, Lau C, et al. Pax6, Tbr2, and Tbr1 are expressed sequentially by radial glia, intermediate progenitor cells, and postmitotic neurons in develo** neocortex[J]. Journal of Neuroscience, 2005, 25(1): 247-251. https://doi.org/10.1523/JNEUROSCI.2899-04.2005
- 7. Jurga A M, Paleczna M, Kadluczka J, et al. Beyond the GFAP-astrocyte protein markers in the brain[J]. Biomolecules, 2021, 11(9): 1361. https://doi.org/10.3390/biom11091361
- 8. Alekseeva O S, Gusel’nikova V V, Beznin G V, et al. Prospects for the application of neun nuclear protein as a marker of the functional state of nerve cells in vertebrates[J]. Journal of Evolutionary Biochemistry and Physiology, 2015, 51: 357-369. https://doi.org/10.1134/S0022093015050014
- Introduction
- Product List
- Verification Data
- References