Alpha-Synuclein Overview
Molecule Name
Synuclein alpha
Synonyms
SNCA,NACP,PARK1,alpha-Synuclein
Drug Development Progress
Drugs in Clinical Trials25
Approved Drugs0
Highest Development StagePhase 3 Clinical
Target Synonym
Truncated Alpha Synuclein，Α-Synuclein，PARK1，SNCA，Synuclein Alpha，Synuclein， Alpha (Non A4 Component Of Amyloid Precursor)，NACP，Parkinson Disease (Autosomal Dominant， Lewy Body) 4，Non-A4 Component Of Amyloid Precursor，Non A4 Component Of Amyloid Precursor，Non A-Beta Component Of AD Amyloid，Non-A Beta Component Of AD Amyloid，Synuclein Alpha-140，I+/--Synuclein，α-Synuclein，PARK4，alpha-Synuclein
Background
Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.
Alpha-Synuclein Product List
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