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Cadherin-17

Cadherin-17

Cadherin-17 Overview

Molecule Name
Cadherin-17
Synonyms
Cadherin-17,CDH17,HPT-1,LI-cadherin
Drug Development Progress
Drugs in Clinical Trials17
Approved Drugs0
Highest Development StagePhase 2 Clinical
Target Synonym
Liver-intestine cadherin，HPT-1，Intestinal peptide-associated transporter HPT-1，LI-cadherin，HPT-1 Cadherin，Cadherin 17， LI Cadherin (Liver-Intestine)，HPT1，Human Intestinal Peptide-Associated Transporter HPT-1，LI Cadherin，Cadherin，Cadherin 17，Human Peptide Transporter 1
Background
Cadherin-17, also known as liver-intestine (LI) Cadherin, belongs to the cadherin family of calcium-dependent cell adhesion molecules. In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.

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