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Home PageAll MoleculesCLEC4C
CLEC4C
CLEC4C Overview
| English Name | C-Type lectin domain family 4 member C | Approved Drugs | 0 |
| Drugs in Clinical Trials | 4 | Target Synonym | DLEC，HECL，C-type lectin superfamily member 7，CLEC4C，BDCA2，UNQ9361/PRO34150，C-type lectin domain family 4 member C，Dendritic lectin，C-Type (Calcium Dependent， Carbohydrate-Recognition Domain) Lectin， Superfamily Member 7，C-Type Lectin Domain Family 4， Member C，CLECSF11，CLECSF7，BDCA-2，C-Type (Calcium Dependent， Carbohydrate-Recognition Domain) Lectin， Superfamily Member 11，Blood Dendritic Cell Antigen 2 Protein，Blood Dendritic Cell Antigen 2，Dendritic Cell Lectin B，CD303 Antigen，PRO34150，CD303 |
| Highest Development Stage | Phase 3 Clinical | ||
| English Name | C-Type lectin domain family 4 member C |
| Target Synonym | DLEC，HECL，C-type lectin superfamily member 7，CLEC4C，BDCA2，UNQ9361/PRO34150，C-type lectin domain family 4 member C，Dendritic lectin，C-Type (Calcium Dependent， Carbohydrate-Recognition Domain) Lectin， Superfamily Member 7，C-Type Lectin Domain Family 4， Member C，CLECSF11，CLECSF7，BDCA-2，C-Type (Calcium Dependent， Carbohydrate-Recognition Domain) Lectin， Superfamily Member 11，Blood Dendritic Cell Antigen 2 Protein，Blood Dendritic Cell Antigen 2，Dendritic Cell Lectin B，CD303 Antigen，PRO34150，CD303 |
| Approved Drugs | 0 |
| Drugs in Clinical Trials | 4 |
| Highest Development Stage | Phase 3 Clinical |
CLEC4C Product List
- Product Category
Protein (5)
- Product Status
Launched (5)
- Species
Human (3)Cynomolgus (2)
- Tag
Fc Tag (2)His Tag (2)His Tag & Avi Tag (1)
- Conjugate
Unconjugated (4)Biotin-labeled (1)
| Cat. No. | Species | Host | Product Description | Structure | Purity | Feature |
|---|---|---|---|---|---|---|
HOT CLC-H5245 |  Human | HEK293 | Human CLEC4C / BDCA2 Protein, His Tag |  |  |  |
CLC-H5254 | Human | HEK293 | Human CLEC4C / BDCA2 Protein, Fc Tag |  | | |
CLC-H82Q3 | Human | HEK293 | Biotinylated Human CLEC4C / BDCA2 Protein, Avitag™,His Tag |  | | |
CLC-C5253 |  Cynomolgus | HEK293 | Cynomolgus CLEC4C / BDCA2 Protein, Fc Tag (MALS verified) |  | | |
CLC-C52H4 | Cynomolgus | HEK293 | Cynomolgus CLEC4C / BDCA2 Protein, His Tag (MALS verified) |  | | |
Total: 5
- 1
CLEC4C Background
CLEC4C (C-type lectin domain family 4 member C), also known as BDCA2, CLECSF11, CLECSF7, DLEC and CD303. Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cell. Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man. Binds to serum IgG. Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium.
CLEC4C Synonyms
DLEC,CLEC4C,BDCA-2,CD303,CLECSF11,CLECSF7, HECL
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| Litifilimab | BIIB-059 | Phase 3 Clinical | Biogen Inc | Lupus Erythematosus, Cutaneous; Lupus Erythematosus, Systemic | Details |
| SSGJ-626 | SSGJ-626; 626 | Phase 1 Clinical | Sunshine GuoJian Pharmaceutical (Shanghai) Co Ltd | Lupus Erythematosus, Cutaneous; Lupus Erythematosus, Systemic | Details |
| Recombinant anti-BDCA2 humanized monoclonal antibody (Sansheng Guojian) | Phase 1 Clinical | Sunshine GuoJian Pharmaceutical (Shanghai) Co Ltd | Lupus Erythematosus, Cutaneous; Lupus Erythematosus, Systemic | Details | |
| DB-2304 | DB-2304 | Phase 1 Clinical | Duality Biologics (Suzhou) Co Ltd | Autoimmune Diseases | Details |
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