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Home PageAll MoleculesDDR1
DDR1
DDR1 Overview
| English Name | Discoidin domain receptor 1 | Approved Drugs | 0 |
| Drugs in Clinical Trials | 5 | Target Synonym | Epithelial discoidin domain-containing receptor 1，Epithelial discoidin domain receptor 1，CD167 antigen-like family member A，Cell adhesion kinase，Discoidin receptor tyrosine kinase，HGK2，Mammary carcinoma kinase 10，MCK-10，Protein-tyrosine kinase 3A，Protein-tyrosine kinase RTK-6，TRK E，Tyrosine kinase DDR，Tyrosine-protein kinase CAK，CD167a，CD167 Antigen-Like Family Member A，TRKE，RTK6，PTK3A Protein Tyrosine Kinase 3A，PTK3A，NTRK4，Neurotrophic Tyrosine Kinase， Receptor， Type 4，Neuroepithelial Tyrosine Kinase，NEP，MCK10，EDDR1，Discoidin Domain Receptor Tyrosine Kinase 1，Discoidin Domain Receptor Family， Member 1，CD167a Antigen，CAK，CD167 |
| Highest Development Stage | Phase 2 Clinical | ||
| English Name | Discoidin domain receptor 1 |
| Target Synonym | Epithelial discoidin domain-containing receptor 1，Epithelial discoidin domain receptor 1，CD167 antigen-like family member A，Cell adhesion kinase，Discoidin receptor tyrosine kinase，HGK2，Mammary carcinoma kinase 10，MCK-10，Protein-tyrosine kinase 3A，Protein-tyrosine kinase RTK-6，TRK E，Tyrosine kinase DDR，Tyrosine-protein kinase CAK，CD167a，CD167 Antigen-Like Family Member A，TRKE，RTK6，PTK3A Protein Tyrosine Kinase 3A，PTK3A，NTRK4，Neurotrophic Tyrosine Kinase， Receptor， Type 4，Neuroepithelial Tyrosine Kinase，NEP，MCK10，EDDR1，Discoidin Domain Receptor Tyrosine Kinase 1，Discoidin Domain Receptor Family， Member 1，CD167a Antigen，CAK，CD167 |
| Approved Drugs | 0 |
| Drugs in Clinical Trials | 5 |
| Highest Development Stage | Phase 2 Clinical |
DDR1 Product List
- Product Category
Protein (3)
- Product Status
Launched (3)
- Species
Human (2)Mouse (1)
- Tag
Fc Tag (2)His Tag & Avi Tag (1)
- Conjugate
Unconjugated (2)Biotin-labeled (1)
| Cat. No. | Species | Host | Product Description | Structure | Purity | Feature | Order Now |
|---|---|---|---|---|---|---|---|
HOT DD1-H82E9 |  Human | HEK293 | Biotinylated Human DDR1 Protein, His,Avitag™ (MALS verified) |  |  |  |  Add to Cart |
DD1-H5258 | Human | HEK293 | Human DDR1 Protein, Fc Tag |  | | | Add to Cart |
DD1-M5259 |  Mouse | HEK293 | Mouse DDR1 Protein, Fc Tag |  | |  | Add to Cart |
Total: 3
- 1
DDR1 Background
Discoidin domain receptor 1 (DDR1) is a member of DDRs, which are members of the receptor tyrosine kinase (RTK). Upon collagen binding, DDR1 undergoes tyrosine autophosphorylation, which consequently triggers downstream genetic and cellular pathways and plays critical roles in the regulation of cellular morphogenesis, differentiation, proliferation, adhesion, migration, and invasion. Research shows that DDR1 is closely related to various human diseases including cancer, fibrosis, atherosclerosis, and other inflammatory disorders. New generation DDR1 inhibitors targeting the allosteric sites outside of the canonical ATP-binding pocket or extracellular domain (allosteric inhibitors) may offer a new opportunity for selective DDR1 inhibition therapy development.
DDR1 Synonyms
CD167a
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| Merestinib | 5OGS5K699E; LY-2801653 | Phase 2 Clinical | Eli Lilly And Company | Biliary Tract Neoplasms; Solid tumours; Skin Melanoma; Bone metastases; Pancreatic Neoplasms; Neoplasms; Microsatellite instability-high cancer; Breast Neoplasms; Cholangiocarcinoma; Lymphoma, Mantle-Cell; Colorectal Neoplasms; Gallbladder Neoplasms; Lymphoma, Non-Hodgkin; Leukemia, Myeloid, Acute; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung | Details |
| PRTH-101 | PRTH-101 | Phase 1 Clinical | The George Washington University Milken Institute School Of Public Health (Gwu), Parthenon Therapeutics Inc | Solid tumours; Neoplasms | Details |
| ICP-033 | ICP-033 | Phase 1 Clinical | Beijing Innocare Pharma Tech Co Ltd | Solid tumours | Details |
| AVI-4015 | AVI-4015 | Phase 1 Clinical | Avixgen | Dry Eye Syndromes | Details |
| AGX-0073 | AGX-0073 | Phase 1 Clinical | Shanghai Aojian Biological Technology Co Ltd | Solid tumours | Details |
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