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IL-4
IL-4 Overview
| English Name | Interleukin-4 | Approved Drugs | 2 |
| Drugs in Clinical Trials | 7 | Target Synonym | MGC79402，B-cell stimulatory factor 1，Lymphocyte stimulatory factor 1，IL4，Interleukin 4，B_cell Stimulatory Factor 1，B Cell Growth Factor 1，Binetrakin，Pitrakinra，BSF-1，IL-4，Interleukin 4 Variant 2，BCGF-1，BCGF1，BSF1，Interleukin-4 |
| Highest Development Stage | Approved | ||
| English Name | Interleukin-4 |
| Target Synonym | MGC79402，B-cell stimulatory factor 1，Lymphocyte stimulatory factor 1，IL4，Interleukin 4，B_cell Stimulatory Factor 1，B Cell Growth Factor 1，Binetrakin，Pitrakinra，BSF-1，IL-4，Interleukin 4 Variant 2，BCGF-1，BCGF1，BSF1，Interleukin-4 |
| Approved Drugs | 2 |
| Drugs in Clinical Trials | 7 |
| Highest Development Stage | Approved |
IL-4 Product List
- Product Category
Protein (11)Kits (5)
- Product Status
Launched (16)
- Species
Human (10)Mouse (3)Cynomolgus (3)
- Tag
Tag Free (3)His Tag & Avi Tag (3)His Tag (3)Fc Tag (2)- (5)
- Conjugate
Unconjugated (8)Biotin-labeled (3)- (5)
| Cat. No. | Species | Host | Product Description | Structure | Purity | Feature |
|---|---|---|---|---|---|---|
HOT GMP-L04H26 |  Human | HEK293 | GMP Human IL-4 Protein |  |  |  |
HOT IL4-H4218 | Human | HEK293 | Human IL-4 Protein, premium grade |  | |  |
HOT IL4-H5253 | Human | HEK293 | Human IL-4 Protein, Fc Tag (MALS verified) |  | | |
HOT IL4-H52H9 | Human | HEK293 | Human IL-4 Protein, His Tag, low endotoxin (MALS verified) |  | | |
HOT IL4-H82E0 | Human | HEK293 | Biotinylated Human IL-4 Protein, Avitag™,His Tag (MALS verified) |  | | |
CRS-A004 | Human | - | resDetect™ Human Interleukin-4 (IL-4) ELISA Kit (Residue Testing) | |||
CRS-B003 | Human | - | Human IL-4 ELISA Kit | |||
EP-132 | Human | - | IL-4 [Biotinylated] : IL-4Rα Inhibitor Screening ELISA Kit | |||
FCSh-002 | Human | - | Human IL-4 Detection Kit (Flow Cytometry Bead Assay) | |||
IL4-H5219 | Human | HEK293 | Human IL-4 Protein, Research Grade |  | | |
Total: 16
- 1
- 2
IL-4 Background
Interleukin-4, is a cytokine that induces differentiation of naive helper T cells (Th0 cells to Th2 cells). In the presence of IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated, And this cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. Recently, researcher found that the cytokine IL-4 plays a key role in development of innate CD8+ T cells in the thymus of several gene-deficient mouse strains, including Itk, KLF2, CBP and Id3, without previous exposure to antigen.
IL-4 Synonyms
IL4,BCGF1,BSF1
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| Eblasakimab | MK-6105; ASLAN-004; CSL-334 | Phase 2 Clinical | Csl Ltd, Merck Sharp & Dohme Corp | Dermatitis, Atopic; Hypersensitivity | Details |
| Dectrekumab/VAK-694 | QBX-258 | Phase 2 Clinical | Novartis Pharma Ag | Lymphedema; Asthma | Details |
| OCH-NCNP1 | OCH-NCNP1 | Phase 2 Clinical | Keio University | Multiple Sclerosis; Crohn Disease | Details |
| PF-07264660 | PF-07264660 | Phase 2 Clinical | Pfizer Inc | Dermatitis, Atopic | Details |
| PF-07275315 | PF-07275315 | Phase 2 Clinical | Pfizer Inc | Dermatitis, Atopic | Details |
| AUP1602-C | AUP-16; AUP1602-C | Phase 2 Clinical | Aurealis | Diabetic Foot; Ulcer | Details |
| KBL-693 | KBL-693 | Phase 1 Clinical | Kobiolabs | Asthma | Details |
Marketed Drug Information
| English Name | Research Code | Highest Development Stage | Company | Earliest Brand Name | Earliest Approval Country | Earliest Indication | Earliest Approval Company | Earliest Approval Date | Indication | Clinical Trial |
|---|---|---|---|---|---|---|---|---|---|---|
| Dupilumab | SAR-231893; REGN-668 | Approved | Sanofi, Regeneron Pharmaceuticals Inc | Dupixent, 达必妥 | United States | Dermatitis, Atopic | Regeneron Pharmaceuticals Inc | 2017-03-28 | Pulmonary Disease, Chronic Obstructive; Sleep Apnea Syndromes; Sinusitis; Asthma; Colitis, Ulcerative; Duodenitis; Pemphigoid, Bullous; Neurodermatitis; Urticaria; Prurigo; Keloid; Conjunctivitis, Allergic; Paranasal Sinus Diseases; Scleroderma, Localized; Keratoconjunctivitis; Asthma, Aspirin-Induced; Peanut Hypersensitivity; Hypersensitivity, Immediate; Dermatitis, Atopic; Angioedema; Eczema; Hypersensitivity; Milk Hypersensitivity; Aspergillosis, Allergic Bronchopulmonary; Lichenoid Eruptions; Hypereosinophilic Syndrome; Gastrointestinal Diseases; Pruritus; Respiratory Sounds; Alopecia Areata; Chronic Urticaria; Nasal Polyps; Respiration Disorders; Eosinophilic gastroenteritis (EG); Respiratory Tract Diseases; Coronavirus Disease 2019 (COVID-19); Dermatitis; Prurigo Nodularis; Genetic Diseases, Inborn; Skin Diseases, Eczematous; Skin Diseases; Prostatic Neoplasms; Eosinophilic Esophagitis; Rhinitis, Allergic | Details |
| Berdazimer sodium | NVN-1000-SB-206-Novan; SB-206; MAP3-NONOate - SB-206; NVN1000-SB206; SB-019; NI-MC101; SB-207; SB-208; SB-204; SB-414 | Approved | Novan Inc | Zelsuvmi, ZELSUVMI, KINSOLUSTM | United States | Molluscum Contagiosum | Lnhc Inc | 2024-01-05 | Acne Vulgaris; Tinea Pedis; Psoriasis; Molluscum Contagiosum; Condylomata Acuminata; Dermatitis, Atopic | Details |
Product Reviews
Y***G2025-11-07
0People LikeInitially used ACRO's TROP-2 protein with FC tag for animal immunization, the immunization effect is very satisfactory. Recently repurchased the his tag protein for antibody affinity detection, the obtained EC50 data is also very good, and the specificity is strong.- Z***N2025-11-07 0People LikeWe purchased this IL-4 Protein mainly for characterization analysis and PK detection. The experimental results were good, method development was smooth, results met expectations, and the curves were good. Will repurchase if needed in the future.
- M***e2023-06-15 3People LikeWe have used this kit to profile compounds. This kit is both reliable and easy to use, and it shipped quickly. The 96 test kit is also amenable to scaling to a 384 well format for additional screening capabilities. In our experience, the customer service at ACRO has always been prompt when inquiring about when items will be restocked and when they have shipped.
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