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IL-6 R alpha
IL-6 R alpha Overview
| English Name | Interleukin-6 receptor alpha subunit | Approved Drugs | 8 |
| Drugs in Clinical Trials | 10 | Target Synonym | IL6RA，IL6RQ，IL6Q，Interleukin-6 Receptor alpha Subunit，sIL6R，gp80，IL-6R subunit alpha，Membrane glycoprotein 80，IL6R，Interleukin 6 Receptor，IL-6 Receptor Subunit Alpha，CD126 Antigen，IL-6R 1，IL-6RA，Interleukin-6 Receptor Subunit Alpha，IL-6R-Alpha，IL-6R-1，CD126 |
| Highest Development Stage | Approved | ||
| English Name | Interleukin-6 receptor alpha subunit |
| Target Synonym | IL6RA，IL6RQ，IL6Q，Interleukin-6 Receptor alpha Subunit，sIL6R，gp80，IL-6R subunit alpha，Membrane glycoprotein 80，IL6R，Interleukin 6 Receptor，IL-6 Receptor Subunit Alpha，CD126 Antigen，IL-6R 1，IL-6RA，Interleukin-6 Receptor Subunit Alpha，IL-6R-Alpha，IL-6R-1，CD126 |
| Approved Drugs | 8 |
| Drugs in Clinical Trials | 10 |
| Highest Development Stage | Approved |
IL-6 R alpha Product List
- Product Category
Protein (7)
- Product Status
Launched (7)
- Species
Human (4)Mouse (2)Rhesus macaque (1)
- Tag
His Tag (2)His Tag & Avi Tag (2)Fc Tag (2)Fc Tag & Avi Tag (1)
- Conjugate
Unconjugated (4)Biotin-labeled (3)
| Cat. No. | Species | Host | Product Description | Structure | Purity | Feature |
|---|---|---|---|---|---|---|
HOT CD6-H82E8 |  Human | HEK293 | Biotinylated Human IL-6 R alpha / CD126 Protein, Avitag™,His Tag (MALS verified) |  |  |  |
HOT ILR-H4223 | Human | HEK293 | Human IL-6 R alpha / CD126 Protein, His Tag (MALS verified) |  | | |
HOT ILR-H5259 | Human | HEK293 | Human IL-6 R alpha / CD126 Protein, Fc Tag |  | | |
HOT ILR-H82F9 | Human | HEK293 | Biotinylated Human IL-6 R alpha / CD126 Protein, Fc,Avitag™ |  | | |
ILR-M5255 |  Mouse | HEK293 | Mouse IL-6 R alpha / CD126 Protein, Fc Tag (MALS verified) |  | | |
ILR-M82E9 | Mouse | HEK293 | Biotinylated Mouse IL-6 R alpha / CD126 Protein, His,Avitag™ |  | | |
ILR-R52H7 |  Rhesus macaque | HEK293 | Rhesus macaque IL-6 R alpha / CD126 Protein, His Tag (MALS verified) |  | | |
Total: 7
- 1
IL-6 R alpha Synonyms
IL6R,CD126,IL-6R-1,IL-6RA,IL6RA,IL-6R-alpha,IL6RQ,gp80
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| Recombinant humanized anti-IL-6R antibody (Hisun Pharma) | HS-628 | Phase 3 Clinical | Zhejiang Hisun Pharmaceutical Co Ltd | Arthritis, Rheumatoid; Arthritis | Details |
| VDJ-001 | Phase 3 Clinical | Beijing Vdjbio Co Ltd | Arthritis, Rheumatoid; Multicentric Castleman's Disease (MCD) | Details | |
| Tocilizumab Biosimilar (Curateq Biologics) | BP08; BP-08 | Phase 3 Clinical | Arthritis, Rheumatoid | Details | |
| Tocilizumab biosimilar (GENERIUM Pharmaceuticals) | GNR-087 | Phase 3 Clinical | Generium Pharmaceuticals | Arthritis, Rheumatoid | Details |
| Tocilizumab biosimilar (AryoGen Pharmed) | Phase 3 Clinical | Aryogen Biopharma | Arthritis, Rheumatoid | Details | |
| Tocilizumab biosimilar(Hetero Biopharma) | Phase 3 Clinical | Hetero Biopharma Ltd | Coronavirus Disease 2019 (COVID-19); Arthritis, Rheumatoid | Details | |
| Levilimab | BCD-089 | Phase 3 Clinical | BIOCAD JSC | Coronavirus Disease 2019 (COVID-19); Arthritis, Rheumatoid | Details |
| Olamkicept | FE-999301; CR-5/18; TJ-301; FE-301 | Phase 2 Clinical | Conaris Research Institute | Gastrointestinal Diseases; Colitis, Ulcerative | Details |
| Atexakin alfa | SON-080; r-IL-6 | Phase 2 Clinical | Weizmann Institute Of Science | Peripheral Nervous System Diseases; Diabetic Neuropathies | Details |
| Tocilizumab Biosimilar (Destiny) | IA-001; IA001 | Phase 1 Clinical | Shanghai Destiny Biotech Co Ltd | Polyarticular Juvenile Idiopathic Arthritis; Arthritis, Rheumatoid | Details |
Marketed Drug Information
| English Name | Research Code | Highest Development Stage | Company | Earliest Brand Name | Earliest Approval Country | Earliest Indication | Earliest Approval Company | Earliest Approval Date | Indication | Clinical Trial |
|---|---|---|---|---|---|---|---|---|---|---|
| Tocilizumab | rhPM-1; RO-48775533; RG-1569; MRA; HPM-1; MRA-SC; R-1569 | Approved | Chugai Pharmaceutical Co Ltd | Actemra, RoActemra, 雅美罗, Actemra/RoActemra, Acterma | Japan | Arthritis, Juvenile; Arthritis, Rheumatoid; Giant Cell Arteritis; Takayasu Arteritis; Cytokine Release Syndrome; Multicentric Castleman's Disease (MCD) | null | 2005-04-11 | Lymphoma; Graves Ophthalmopathy; Ascites; Takayasu Arteritis; Pancreatitis, Chronic; Coronavirus Infections; Pulmonary Arterial Hypertension; Coronary Disease; Lupus Erythematosus, Systemic; Breast Neoplasms; systemic sclerosis-associated interstitial lung disease; Multicentric Castleman's Disease (MCD); Fever; Uveitis, Posterior; Stroke; Pulmonary Disease, Chronic Obstructive; Osteoarthritis; Uveitis; Rejection in heart transplantation; Inflammation; Pleural Effusion, Malignant; Panuveitis; Diabetes Mellitus; Behcet Syndrome; Amyotrophic Lateral Sclerosis; Anemia, Sickle Cell; Carcinoma, Hepatocellular; Non-ST Elevated Myocardial Infarction; Myocardial Infarction; Hematologic Neoplasms; Solid tumours; Cytokine Release Syndrome; Motor Neuron Disease; HIV Infections; Diabetes Mellitus, Type 1; Acute Chest Syndrome; Craniopharyngioma; Polymyositis; Giant Cell Arteritis; Schnitzler Syndrome; Depressive Disorder, Major; Polyarticular Juvenile Idiopathic Arthritis; Non-radiographic axial spondyloarthritis; Uveitis | Details |
| Tocilizumab biosimilar (Bio-Thera Solutions) | BAT-1806; BIIB-800 | Approved | Bio-Thera Solutions Ltd | 施瑞立, TOFIDENCE | Mainland China | Arthritis, Rheumatoid; Arthritis, Juvenile; Cytokine Release Syndrome | Bio-Thera Solutions Ltd | 2023-01-16 | Cytokine Release Syndrome; Polyarticular Juvenile Idiopathic Arthritis; Arthritis, Rheumatoid; Coronavirus Disease 2019 (COVID-19); Arthritis, Juvenile | Details |
| Sarilumab | SAR-153191; REGN-88 | Approved | Sanofi, Regeneron Pharmaceuticals Inc | Kevzara | United States | Arthritis, Rheumatoid | Sanofi-Synthelabo | 2017-05-22 | Polyarticular Juvenile Idiopathic Arthritis; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Coronavirus Disease 2019 (COVID-19); Mastocytosis, Systemic; Sarcoidosis; Arthritis, Juvenile; Polymyalgia Rheumatica; Severe Acute Respiratory Syndrome; Uveitis | Details |
| Tocilizumab biosimilar (Livzon Group) | LZM-008 | Approved | Livzon Pharmaceutical Group Inc | 安维泰 | Mainland China | Arthritis, Rheumatoid | Livzon Mabpharm Inc | 2023-01-18 | Arthritis, Rheumatoid | Details |
| Tocilizumab biosimilar (Fresenius kabi) | MSB-11456; AT-220 (Arecor Therapeutics) | Approved | Merck Serono | Tyenne | EU | Coronavirus Disease 2019 (COVID-19); Cytokine Release Syndrome; Arthritis, Rheumatoid; Giant Cell Arteritis | Fresenius Kabi Deutschland Gmbh | 2023-09-15 | Brain Ischemia; Cytokine Release Syndrome; Giant Cell Arteritis; Polyarticular Juvenile Idiopathic Arthritis; Coronavirus Disease 2019 (COVID-19); Arthritis, Rheumatoid; Subarachnoid Hemorrhage | Details |
| Tocilizumab biosimilar (BioRay Pharm) | Approved | Hisun Biopharmaceutical Co Ltd | Mainland China | Arthritis, Rheumatoid | Hisun Biopharmaceutical Co Ltd | 2024-06-25 | Arthritis, Rheumatoid | Details | ||
| Tocilizumab biosimilar (Celltrion) | CT-P47; CT-P-47 | Approved | Celltrion Inc | Avtozma | United States | Giant Cell Arteritis; Polyarticular Juvenile Idiopathic Arthritis; Coronavirus Disease 2019 (COVID-19); Arthritis, Juvenile; Arthritis, Rheumatoid | Celltrion Inc | 2025-01-24 | Giant Cell Arteritis; Polyarticular Juvenile Idiopathic Arthritis; Coronavirus Disease 2019 (COVID-19); Arthritis, Rheumatoid; Arthritis, Juvenile | Details |
| Tocilizumab biosimilar (Maibo Taike) | CMAB-806; CMAB806 | Approved | Taizhou Maibo Taike Biotechnology Co Ltd, Jinyu Bowo Runze Biotechnology Co Ltd | Mainland China | Arthritis, Rheumatoid | Jinyu Bowo Runze Biotechnology Co Ltd | 2024-10-16 | Arthritis, Rheumatoid; Arthritis | Details |
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