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Osteoactivin

Osteoactivin Overview

English NameTransmembrane glycoprotein NMBApproved Drugs0
Drugs in Clinical Trials2Target SynonymTransmembrane Glycoprotein，HGFIN，Transmembrane glycoprotein NMB，Hematopoietic growth factor inducible neurokinin-1 type，GPNMB，Glycoprotein Nmb，Hematopoietic Growth Factor Inducible Neurokinin-1，Glycoprotein Nonmetastatic Melanoma Protein B，Transmembrane Glycoprotein HGFIN，Glycoprotein (Transmembrane) Nmb，Glycoprotein Nmb-Like Protein，Osteoactivin，PLCA3，NMB，UNQ1725/PRO9925
Highest Development StagePhase 2 Clinical
English NameTransmembrane glycoprotein NMB
Target SynonymTransmembrane Glycoprotein，HGFIN，Transmembrane glycoprotein NMB，Hematopoietic growth factor inducible neurokinin-1 type，GPNMB，Glycoprotein Nmb，Hematopoietic Growth Factor Inducible Neurokinin-1，Glycoprotein Nonmetastatic Melanoma Protein B，Transmembrane Glycoprotein HGFIN，Glycoprotein (Transmembrane) Nmb，Glycoprotein Nmb-Like Protein，Osteoactivin，PLCA3，NMB，UNQ1725/PRO9925
Approved Drugs0
Drugs in Clinical Trials2
Highest Development StagePhase 2 Clinical

Osteoactivin Product List

  • Product Category

    Protein (1)

  • Product Status

    Launched (1)

  • Species

    Human (1)

  • Tag

    His Tag (1)

  • Conjugate

    Unconjugated (1)

Cat. No.SpeciesHostProduct DescriptionStructurePurityFeatureOrder Now
GPB-H5229
Human
HEK293
Human Osteoactivin / GPNMB Protein, His Tag
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Total: 1
  • 1

Osteoactivin Background

Transmembrane glycoprotein NMB (GPNMB) is also known as Transmembrane glycoprotein HGFIN, DC-HIL and Osteoactivin (OA), which belongs to the PMEL/NMB family. GPNMB contains one PKD domain. GPNMB is a transmembrane glycoprotein that is up-regulated in various cancer cells, including in glioblastoma multiforme and is expressed in many melanoma cells, as well as in tissue macrophages. GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function. GPNMB participates in bone mineralization, and functions as a negative regulator of inflammation in macrophages.

Osteoactivin Synonyms

GPNMB,HGFIN,NMB,Osteoactivin

Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
Glembatumumab vedotinCR-011; CDX-011; CR-011-ADC; CR011-vcMMAEPhase 2 ClinicalCelldex TherapeuticsSolid tumours; Skin Melanoma; Triple Negative Breast Neoplasms; Uveal melanoma; Breast Neoplasms; Osteosarcoma; Carcinoma, Squamous Cell; Melanoma
Details
GPNMB-targeting Chimeric Antigen Receptor T-Cell Therapy (AHS Cancer Control Alberta)GCAR1Phase 1 ClinicalAHS Cancer Control AlbertaSarcoma, Alveolar Soft Part
Details
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  • Clinical Drug Information
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