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Home PageAll MoleculesPD-L2
PD-L2
PD-L2 Overview
| English Name | Programmed death-ligand 2 | Approved Drugs | 0 |
| Drugs in Clinical Trials | 3 | Target Synonym | PDCD1LG2，PDL2，Programmed death ligand 2，CD273，Butyrophilin B7-DC，PD-1 ligand 2，B7-DC，BA574F11.2，PDCD1L2，CD273 Antigen，B7DC，Btdc，B7 Dendritic Cell Molecule，PD-1-Ligand 2，PDCD1 ligand 2，Programmed cell death 1 ligand 2 |
| Highest Development Stage | Phase 3 Clinical | ||
| English Name | Programmed death-ligand 2 |
| Target Synonym | PDCD1LG2，PDL2，Programmed death ligand 2，CD273，Butyrophilin B7-DC，PD-1 ligand 2，B7-DC，BA574F11.2，PDCD1L2，CD273 Antigen，B7DC，Btdc，B7 Dendritic Cell Molecule，PD-1-Ligand 2，PDCD1 ligand 2，Programmed cell death 1 ligand 2 |
| Approved Drugs | 0 |
| Drugs in Clinical Trials | 3 |
| Highest Development Stage | Phase 3 Clinical |
PD-L2 Product List
- Product Category
Protein (8)
- Product Status
Launched (8)
- Species
Human (5)Mouse (3)
- Tag
His Tag (2)Fc Tag (2)Mouse IgG Fc Tag (1)His Tag & Avi Tag (2)Fc Tag & Avi Tag (1)
- Conjugate
Unconjugated (5)Biotin-labeled (3)
| Cat. No. | Species | Host | Product Description | Structure | Purity | Feature |
|---|---|---|---|---|---|---|
HOT PD2-H5220 |  Human | HEK293 | Human PD-L2 / B7-DC Protein, His Tag (SPR verified) |  |  |  |
HOT PD2-H82E8 | Human | HEK293 | Biotinylated Human PD-L2 / B7-DC Protein, Avitag™,His Tag (recommended for biopanning) |  | |  |
HOT PD2-H82F6 | Human | HEK293 | Biotinylated Human PD-L2 / B7-DC Protein, Fc,Avitag™ (MALS verified) |  | | |
HOT PD2-M52E3 |  Mouse | HEK293 | Mouse PD-L2 / B7-DC Protein, His Tag (MALS verified) |  | | |
HOT PD2-M82E3 | Mouse | HEK293 | Biotinylated Mouse PD-L2 / B7-DC Protein, His,Avitag™ (MALS verified) |  | | |
PD2-H5251 | Human | HEK293 | Human PD-L2 / B7-DC Protein, Fc Tag, low endotoxin (MALS verified) |  | | |
PD2-H52A5 | Human | HEK293 | Human PD-L2 / B7-DC Protein, Mouse IgG1 Fc Tag |  | | |
PD2-M5254 | Mouse | HEK293 | Mouse PD-L2 / B7-DC Protein, Fc Tag |  | | |
Total: 8
- 1
PD-L2 Background
Programmed cell death 1 ligand 2 (PD-L2 or PDCD1 ligand 2) is also known as Butyrophilin B7-DC, CD antigen CD273, which belongs to the immunoglobulin superfamily or BTN/MOG family. The expression of PD-L2 is up-regulated by IFNG/IFN-gamma stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL-4. PD-L2 Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. PD-L2 interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
PD-L2 Synonyms
PDL2,PD-L2,Butyrophilin B7-DC,CD273,PDCD1 ligand 2,PDCD1L2,PDCD1LG2
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| IO-120/ IO-103 (IO Biotech) | IO-120/IO-103; IO-120+IO-103 | Phase 2 Clinical | Io Biotech Inc | Leukemia, Lymphocytic, Chronic, B-Cell | Details |
| IMGS-001 | IMGS-001 | Phase 1 Clinical | The University Of Texas MD Anderson Cancer Center | Solid tumours; Neoplasms; Triple Negative Breast Neoplasms; Prostatic Neoplasms; Colorectal Neoplasms | Details |
| IO-120 | IO-120 | Io Biotech Aps | Details |
Product Reviews
1***32019-10-11
0People LikeACROBiosystem's proteins have high purity. They totally meet our requirements. Most importantly, repeatability among batches is very good, and the quality control is great. Thank you!- 1***22019-10-12 0People LikeI purchased the PD-L2 protein for ELISA related experiments. Coating the protein into a well plate, and then adding antibody molecules to incubate with biotin-PD1. I could obtain good stable and repeatable data.
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