TL1A Overview
Molecule Name
Tumor necrosis factor superfamily member 15
Synonyms
TL1A, VEGI, TNFSF15
Drug Development Progress
Drugs in Clinical Trials18
Approved Drugs0
Highest Development StagePhase 3 Clinical
Target Synonym
VEGI192A，Vascular Endothelial Cell Growth Inhibitor，TNF Superfamily Ligand TL1A，TNFSF15，Tumor Necrosis Factor (Ligand) Superfamily， Member 15，Vascular Endothelial Growth Inhibitor-192A，VEGI，TL1A，Tumor Necrosis Factor Ligand 1B，TNLG1B，TNF Superfamily Member 15，Tumor Necrosis Factor Superfamily Member 15，TL1，TNF Ligand-Related Molecule 1，Tumor Necrosis Factor Ligand Superfamily Member 15，MGC129934，MGC129935
Background
TNF-like cytokine 1A (TL1A) and its receptors, death receptor 3 (DR3) and decoy receptor 3 (DcR3) are members of the TNF and TNF receptor superfamilies of proteins, respectively. Binding of APC-derived TL1A to lymphocytic DR3 provides co-stimulatory signals for activated lymphocytes. DR3 signaling affects not only the proliferative activity of and cytokine production by effector lymphocytes, but also critically influences the development and suppressive function of regulatory T-cells. Whereas, DcR3 restricts the function of the TL1A/DR3 complex: attenuating T-cell activation and downregulating the secretion of pro-inflammatory cytokines. Together with DR3 and DcR3, TL1A constitutes a cytokine system that actively interferes with the regulation of immune responses.
TL1A Product List
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S***e2025-09-13Worked all times I have used this product with very reproducible data! Also appreciated the very quick shipping.- A***e2025-04-10I used the TL1A in multiple experiments and the results were always consistent and reproducible. Different lots were used throughout a year long timeline and the results did not differ between lots. When shipping there was not ever any damaged packaging that could impact product quality. I have used Acrobiosystems in my professional career multiple times over multiple years and have always had success :) I will continue to use Acro as a trusted supplier.
- E***r2024-08-08This protein showed good activity in cell reporter assays and could be used routinely in inhibition assays.