Monoclonal Anti-Human CD2 Antibody, Mouse IgG1 (RPA-2.10), Research Grade
Research use only

  • This product is designed for academic and scientific research institutions.
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Product Details

  • Features and Advantages

    1. Native Conformation: Native sequences, tag-free and natural function.
    2. Reliable Activity: Biological activity calibrated against WHO/NIBSC standards.
    3. Stringent Quality Control: Protein content, purity, and cell-based bioactivity testing for each batch.
    4. Lowest Endotoxin level (<0.01 EU/ug).
    5. Safety Assurance: Sterile filtration through 0.2 μm membrane.
    6. AOF: Animal origin-free raw materials throughout the production process.
  • Source

    Monoclonal Anti-Human CD2 Antibody, Mouse IgG1 (RPA-2.10), Research Grade (CD2-C238GN) is a mouse monoclonal antibody recombinantly expressed from human 293 cells (HEK293).

  • Isotype

    Mouse IgG1 | Mouse Kappa

  • Conjugate

    Unconjugated

  • Specificity

    This RPA-2.10 monoclonal antibody specifically reacts with human CD2.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Supplied as 0.2 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Shipping

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • Storage

    For long term storage, the product should be stored at liquid state at -70°C.

    This product is stable after storage at:

    1. -70°C for 24 months.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process
  • Quality Description

    ACRO's Research-grade products are suitable for a wide range of cell culture applications, particularly for research use in academic institutions. These products are sterilized by filtration, followed by lyophilization where applicable. Typical specifications include endotoxin levels of <0.01 EU/μg and purities >95%. Biological activity is calibrated against WHO/NIBSC standards when available.
    ACRO's Premium-grade (Pre-GMP) products are characterized by their high quality and enhanced safety profiles, making them ideal for early-stage discovery and manufacturing processes in cell therapy companies. A key advantage is their seamless transition to corresponding GMP-grade versions. Biological activity is calibrated against WHO/NIBSC standards when available. Typical specifications include endotoxin levels of <0.01 EU/μg and purities >95%. In addition, rigorous testing is conducted to ensure the absence of mycoplasma, HCD, and HCP, thereby guaranteeing product safety.

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Performance Data

  • SDS-PAGE

    CD2 SDS-PAGE

    Monoclonal Anti-Human CD2 Antibody, Mouse IgG1 (RPA-2.10), Research Grade on SDS-PAGE under reducing (R) and non-reducing (NR) conditions. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    CD2 SEC-MALS

    The purity of Monoclonal Anti-Human CD2 Antibody, Mouse IgG1 (RPA-2.10), Research Grade (Cat. No. CD2-C238GN) is more than 95% and the molecular weight of this protein is around 130-160 kDa verified by SEC-MALS.

    Report
  • Bioactivity-FACS

     CD2 FACS

    Flow cytometric analysis of Human peripheral blood lymphocytes respectively staining Monoclonal Anti-Human CD2 Antibody, Mouse IgG1 (RPA-2.10), Research Grade (Cat. No. CD2-C238GN) at 1 μg/mL (0.1 μg corresponds to labeling of 1e6 cells in a final volume of 100 µL) and PE anti-mouse IgG1 Antibody, compared with isotype control antibody. PE signal was used to evaluate the binding activity (QC tested).

    Protocol

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Background

T-cell surface antigen CD2 is also known as Erythrocyte receptor, LFA-2, LFA-3 receptor, Rosette receptor, T-cell surface antigen T11/Leu-5 and SRBC, is a single-pass type I membrane protein found on the surface of T cells and natural killer (NK) cells. CD2 is a member of the immunoglobulin superfamily. CD2 / SRBC contains 1 Ig-like C2-type (immunoglobulin-like) domain and 1 Ig-like V-type (immunoglobulin-like) domain. CD2 / SRBC interacts with other adhesion molecules, such as lymphocyte function-associated antigen-3 (LFA-3 / CD58) in humans, or CD48 in rodents, which are expressed on the surfaces of other cells. In addition to its adhesive properties, CD2 also acts as a co-stimulatory molecule on T and NK cells. CD2 is a specific marker for T cells and NK cells, and can therefore be used in immunohistochemistry to identify the presence of such cells in tissue sections.

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Drug Development Progress
  • English Name:

    T-cell surface antigen CD2

  • Category:

  • Approved Drugs:

    0 Details

  • Drugs in Clinical Trials:

    3 Details

  • Highest Development Stage:

    Phase 2 Clinical

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