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Product Details
Background
Recombinant Monoclonal Anti-Claudin-18.2 Antibody, Mouse (3B10) is a Claudin-18.2 primary antibody for IHC application. The Claudin-18.2 (CLDN 18.2) protein, an isoform of Claudin 18, a member of the tight junction protein family, is a highly selective biomarker with limited expression in normal tissues and often abnormal expression during the occurrence and development of various primary malignant tumors, such as gastric cancer/gastroesophageal junction (GC/GEJ) cancer, breast cancer, colon cancer, liver cancer, head and neck cancer, bronchial cancer and non-small-cell lung cancer. Claudin-18.2 participates in the proliferation, differentiation and migration of tumor cells. Recent studies have identified Claudin-18.2 expression as a potential specific marker for the diagnosis and treatment of these tumors.
Product Specifications
Host SpeciesMouseIsotypeIgGClone3B10ApplicationIHCProperty1：1000StateLiquidPositive ControlHuman Stomach TissuesClonalityMonoclonalResearch FieldCancer Drug TargetsSourceMouseSynonymClaudin18.2, CLDN 18.2Experiment Protocol
Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. The shelf life is 30 days from the date of opening.
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Performance Data
Control Sample
Immunohistochemical analysis of paraffin embedded human stomach tissue labelled with HCS-S278 at 1/1000 dilution.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
Immunohistochemical analysis of paraffin-embedded human lung tissue labeling Claudin-18.2 with HCS-S278 at 1/1000 dilution, followed by Goat Anti-Mouse IgG H&L (HRP) ready to use. The staining in the lung tissue sample was negative. Counter stained with Hematoxylin. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
Cancer Sample
Immunohistochemical analysis of paraffin-embedded human cancer tissue labeling Claudin-18.2 with HCS-S278 at 1/1000 dilution, followed by Goat Anti-Mouse IgG H&L (HRP) ready to use. Membranous staining on tumor cells is observed. Counter stained with Hematoxylin. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
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Drug Development Progress- English Name：
Claudin-18 splice variant 2
- Category：
- Approved Drugs：
1 Details
- Drugs in Clinical Trials：
69 Details
- Highest Development Stage：
Phase 3 Clinical
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