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1/3
COA

Rabbit IL-4 R alpha / CD124 Protein, His Tag (MALS & SPR verified)

AIDD‑Ready
TR-FRET Kit FRT-P009 is now available for advanced research.
1/3
COA
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ILR-R52H8-100ug
$310.00
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ILR-R52H8-1mg (500ug X 2)
$2,060.00
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Product Details
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  • Product Details
  • Performance Data
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  • Important Statement
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Synonyms

IL4R, CD124, IL4RA

Source

Rabbit IL-4 R alpha Protein, His Tag (ILR-R52H8) is expressed from human 293 cells (HEK293). It contains AA Ala 21 - Arg 232 (Accession # A0A5F9DT58).

Predicted N-terminus: Ala 21

Molecular Characterization
Other Tags and Version Biotin & Other Labeled Version

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 25.7 kDa. The protein migrates as 40-53 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin

Less than 1.0 EU per μg by the LAL method / rFC method.

Purity

>95% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Shipping and Storage

This product is shipped at ambient temperature.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • -20°C to -70°C for 12 months in lyophilized state;
  • -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System

Background

Interleukin 4 Receptor (IL4R) also known as CD124, IL4Rα and BSF receptor, is a type I cytokine receptor produced by activated Th2 cells and mast cells, and plays an important role in Th2-­biased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis. A soluble form of the encoded IL4R protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. IL4R can alternatively associate with IL­13Ra1 to form the type II receptor, which is responsive to both IL­4 and IL­13. Interleukin-4 receptor has been shown to interact with SHC1.