B7-CD28 family: significant co-stimulatory pathway in immune regulation

Based on the recognition of antigens in the adaptive immune response, T cell activity is largely achieved during activation, where two signals are required. First, T cell receptors must specifically engage peptides presented by major histocompatibility complexes (MHCs) on antigen presenting cells (APCs); secondly, co-stimulatory/ co-inhibitory receptors on T cells must bind B7 ligand family expressed on APCs to regulate situation of T cell.

This provides a key checkpoint in the regulation of T cell immunity. T cell activation is regulated by the innate immune system through positive and negative costimulatory molecules. Members of the B7 family have been shown to be important for regulating T cell responses. So B7 ligand family plays a significance role in human cancers and autoimmune diseases. The B7 ligand family comprises 11 members, which are B7-1, B7-2, B7-H1, B7-DC, B7-H2, B7-H3, B7-H4, B7-H5, BTNL2, B7-H6 and B7-H7.

ACROBiosystems has developed exclusive B7 family proteins with high purity and high bioactivity, which are suitable for immune, antibody screening, SPR, cell activity detection and other experiments, and can accelerate the development of antibody drugs.

Based on the recognition of antigens in the adaptive immune response, T cell activity is largely achieved during activation, where two signals are required. First, T cell receptors must specifically engage peptides presented by major histocompatibility complexes (MHCs) on antigen presenting cells (APCs); secondly, co-stimulatory/ co-inhibitory receptors on T cells must bind B7 ligand family expressed on APCs to regulate situation of T cell.

This provides a key checkpoint in the regulation of T cell immunity. T cell activation is regulated by the innate immune system through positive and negative costimulatory molecules. Members of the B7 family have been shown to be important for regulating T cell responses. So B7 ligand family plays a significance role in human cancers and autoimmune diseases. The B7 ligand family comprises 11 members, which are B7-1, B7-2, B7-H1, B7-DC, B7-H2, B7-H3, B7-H4, B7-H5, BTNL2, B7-H6 and B7-H7.

ACROBiosystems has developed exclusive B7 family proteins with high purity and high bioactivity, which are suitable for immune, antibody screening, SPR, cell activity detection and other experiments, and can accelerate the development of antibody drugs.

Based on the recognition of antigens in the adaptive immune response, T cell activity is largely achieved during activation, where two signals are required. First, T cell receptors must specifically engage peptides presented by major histocompatibility complexes (MHCs) on antigen presenting cells (APCs); secondly, co-stimulatory/ co-inhibitory receptors on T cells must bind B7 ligand family expressed on APCs to regulate situation of T cell.

This provides a key checkpoint in the regulation of T cell immunity. T cell activation is regulated by the innate immune system through positive and negative costimulatory molecules. Members of the B7 family have been shown to be important for regulating T cell responses. So B7 ligand family plays a significance role in human cancers and autoimmune diseases. The B7 ligand family comprises 11 members, which are B7-1, B7-2, B7-H1, B7-DC, B7-H2, B7-H3, B7-H4, B7-H5, BTNL2, B7-H6 and B7-H7.

ACROBiosystems has developed exclusive B7 family proteins with high purity and high bioactivity, which are suitable for immune, antibody screening, SPR, cell activity detection and other experiments, and can accelerate the development of antibody drugs.

Based on the recognition of antigens in the adaptive immune response, T cell activity is largely achieved during activation, where two signals are required. First, T cell receptors must specifically engage peptides presented by major histocompatibility complexes (MHCs) on antigen presenting cells (APCs); secondly, co-stimulatory/ co-inhibitory receptors on T cells must bind B7 ligand family expressed on APCs to regulate situation of T cell.

This provides a key checkpoint in the regulation of T cell immunity. T cell activation is regulated by the innate immune system through positive and negative costimulatory molecules. Members of the B7 family have been shown to be important for regulating T cell responses. So B7 ligand family plays a significance role in human cancers and autoimmune diseases. The B7 ligand family comprises 11 members, which are B7-1, B7-2, B7-H1, B7-DC, B7-H2, B7-H3, B7-H4, B7-H5, BTNL2, B7-H6 and B7-H7.

ACROBiosystems has developed exclusive B7 family proteins with high purity and high bioactivity, which are suitable for immune, antibody screening, SPR, cell activity detection and other experiments, and can accelerate the development of antibody drugs.

Based on the recognition of antigens in the adaptive immune response, T cell activity is largely achieved during activation, where two signals are required. First, T cell receptors must specifically engage peptides presented by major histocompatibility complexes (MHCs) on antigen presenting cells (APCs); secondly, co-stimulatory/ co-inhibitory receptors on T cells must bind B7 ligand family expressed on APCs to regulate situation of T cell.

This provides a key checkpoint in the regulation of T cell immunity. T cell activation is regulated by the innate immune system through positive and negative costimulatory molecules. Members of the B7 family have been shown to be important for regulating T cell responses. So B7 ligand family plays a significance role in human cancers and autoimmune diseases. The B7 ligand family comprises 11 members, which are B7-1, B7-2, B7-H1, B7-DC, B7-H2, B7-H3, B7-H4, B7-H5, BTNL2, B7-H6 and B7-H7.

ACROBiosystems has developed exclusive B7 family proteins with high purity and high bioactivity, which are suitable for immune, antibody screening, SPR, cell activity detection and other experiments, and can accelerate the development of antibody drugs.