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MHC Complex Custom Service

The core function of the immune system is to identify self, eliminate non-self, maintain normal physiological activities, and prevent invasion by exogenous pathogens. This function is largely mediated by Major Histocompatibility Complex (MHC) molecules, also known as Human Leukocyte Antigen (HLA) in humans. MHC molecules are primarily divided into two classes: MHC-I and MHC-II. MHC-I molecules are found on the surface of almost all nucleated cells and play a crucial role in presenting antigens to CD8+ T cells (cytotoxic T cells). CD8+ T cells can only recognize antigens bound to MHC-I molecules, which are mostly endogenous cellular antigens. In contrast, MHC-II molecules are more limited in distribution and are mainly expressed on antigen-presenting cells such as B cells, monocytes-macrophages, and dendritic cells. The primary function of MHC-II molecules is to present processed antigen fragments to CD4+ T cells, predominantly participating in the presentation of exogenous antigens during the initiation of immune responses.
The T cell receptor (TCR) expressed on T cells can specifically recognize complexes of MHC molecules and peptide fragments and bind to them, which is closely related to immune responses and disease resistance. For example, cytotoxic T lymphocytes (CTLs) with antigen-specificity mainly recognize endogenous antigen peptides bound to MHC-I molecules. Cytotoxic T lymphocytes (CTLs) recognize and bind specific antigenic epitopes presented within the peptide-binding groove of MHC class I molecules on the surface of target cells through their T cell receptors (TCRs). With the assistance of co-stimulatory signals, CTLs are activated, proliferate, and form epitope-specific T cell clones. Activated CTLs then engage target cells through the same mechanism to exert their physiological effects.
Download our MHC product brochure
Download our MHC product brochure

Download our MHC product brochure

Based on the principle of TCR recognition of MHC-peptide complexes, various related drugs have been developed, including TCR-T cell therapy, TCR protein drugs, TCR-like antibodies, and others. To better support MHC-related research, ACROBiosystems relies on their mature protein structure design platform alongside their eukaryotic protein expression technology platform to avoid any prokaryotic refolding process instabilities, incorrect complex conformations, and other issues. Using these platforms, we successfully developed a series of natural MHC complexes with high biological activity in both monomer, tetramer forms with various fluorescent labels available. This includes targets such as NY-ESO-1, WT-1, GP100, GPC, and many others. Furthermore, to meet the diverse needs of our customers, we also offer custom MHC-peptide complex development services using our technology platforms to ensure natural conformation according to your specific needs and applications.
For fluorescently labeled Peptide-MHC tetramers, we offer flexible product formats. In addition to pre-assembled ready-to-use tetramers, you can also easily assemble the desired MHC-peptide complexes by using fluorescently labeled Streptavidin with peptide-free monomers.

Click to Customize

Background

The core function of the immune system is to identify self, eliminate non-self, maintain normal physiological activities, and prevent invasion by exogenous pathogens. This function is largely mediated by Major Histocompatibility Complex (MHC) molecules, also known as Human Leukocyte Antigen (HLA) in humans. MHC molecules are primarily divided into two classes: MHC-I and MHC-II. MHC-I molecules are found on the surface of almost all nucleated cells and play a crucial role in presenting antigens to CD8+ T cells (cytotoxic T cells). CD8+ T cells can only recognize antigens bound to MHC-I molecules, which are mostly endogenous cellular antigens. In contrast, MHC-II molecules are more limited in distribution and are mainly expressed on antigen-presenting cells such as B cells, monocytes-macrophages, and dendritic cells. The primary function of MHC-II molecules is to present processed antigen fragments to CD4+ T cells, predominantly participating in the presentation of exogenous antigens during the initiation of immune responses.
The T cell receptor (TCR) expressed on T cells can specifically recognize complexes of MHC molecules and peptide fragments and bind to them, which is closely related to immune responses and disease resistance. For example, cytotoxic T lymphocytes (CTLs) with antigen-specificity mainly recognize endogenous antigen peptides bound to MHC-I molecules. Cytotoxic T lymphocytes (CTLs) recognize and bind specific antigenic epitopes presented within the peptide-binding groove of MHC class I molecules on the surface of target cells through their T cell receptors (TCRs). With the assistance of co-stimulatory signals, CTLs are activated, proliferate, and form epitope-specific T cell clones. Activated CTLs then engage target cells through the same mechanism to exert their physiological effects.
Download our MHC product brochure
Download our MHC product brochure

Download our MHC product brochure

Based on the principle of TCR recognition of MHC-peptide complexes, various related drugs have been developed, including TCR-T cell therapy, TCR protein drugs, TCR-like antibodies, and others. To better support MHC-related research, ACROBiosystems relies on their mature protein structure design platform alongside their eukaryotic protein expression technology platform to avoid any prokaryotic refolding process instabilities, incorrect complex conformations, and other issues. Using these platforms, we successfully developed a series of natural MHC complexes with high biological activity in both monomer, tetramer forms with various fluorescent labels available. This includes targets such as NY-ESO-1, WT-1, GP100, GPC, and many others. Furthermore, to meet the diverse needs of our customers, we also offer custom MHC-peptide complex development services using our technology platforms to ensure natural conformation according to your specific needs and applications.
For fluorescently labeled Peptide-MHC tetramers, we offer flexible product formats. In addition to pre-assembled ready-to-use tetramers, you can also easily assemble the desired MHC-peptide complexes by using fluorescently labeled Streptavidin with peptide-free monomers.

Click to Customize

Background

The core function of the immune system is to identify self, eliminate non-self, maintain normal physiological activities, and prevent invasion by exogenous pathogens. This function is largely mediated by Major Histocompatibility Complex (MHC) molecules, also known as Human Leukocyte Antigen (HLA) in humans. MHC molecules are primarily divided into two classes: MHC-I and MHC-II. MHC-I molecules are found on the surface of almost all nucleated cells and play a crucial role in presenting antigens to CD8+ T cells (cytotoxic T cells). CD8+ T cells can only recognize antigens bound to MHC-I molecules, which are mostly endogenous cellular antigens. In contrast, MHC-II molecules are more limited in distribution and are mainly expressed on antigen-presenting cells such as B cells, monocytes-macrophages, and dendritic cells. The primary function of MHC-II molecules is to present processed antigen fragments to CD4+ T cells, predominantly participating in the presentation of exogenous antigens during the initiation of immune responses.
The T cell receptor (TCR) expressed on T cells can specifically recognize complexes of MHC molecules and peptide fragments and bind to them, which is closely related to immune responses and disease resistance. For example, cytotoxic T lymphocytes (CTLs) with antigen-specificity mainly recognize endogenous antigen peptides bound to MHC-I molecules. Cytotoxic T lymphocytes (CTLs) recognize and bind specific antigenic epitopes presented within the peptide-binding groove of MHC class I molecules on the surface of target cells through their T cell receptors (TCRs). With the assistance of co-stimulatory signals, CTLs are activated, proliferate, and form epitope-specific T cell clones. Activated CTLs then engage target cells through the same mechanism to exert their physiological effects.
Download our MHC product brochure
Download our MHC product brochure

Download our MHC product brochure

Based on the principle of TCR recognition of MHC-peptide complexes, various related drugs have been developed, including TCR-T cell therapy, TCR protein drugs, TCR-like antibodies, and others. To better support MHC-related research, ACROBiosystems relies on their mature protein structure design platform alongside their eukaryotic protein expression technology platform to avoid any prokaryotic refolding process instabilities, incorrect complex conformations, and other issues. Using these platforms, we successfully developed a series of natural MHC complexes with high biological activity in both monomer, tetramer forms with various fluorescent labels available. This includes targets such as NY-ESO-1, WT-1, GP100, GPC, and many others. Furthermore, to meet the diverse needs of our customers, we also offer custom MHC-peptide complex development services using our technology platforms to ensure natural conformation according to your specific needs and applications.
For fluorescently labeled Peptide-MHC tetramers, we offer flexible product formats. In addition to pre-assembled ready-to-use tetramers, you can also easily assemble the desired MHC-peptide complexes by using fluorescently labeled Streptavidin with peptide-free monomers.

Click to Customize

Background

The core function of the immune system is to identify self, eliminate non-self, maintain normal physiological activities, and prevent invasion by exogenous pathogens. This function is largely mediated by Major Histocompatibility Complex (MHC) molecules, also known as Human Leukocyte Antigen (HLA) in humans. MHC molecules are primarily divided into two classes: MHC-I and MHC-II. MHC-I molecules are found on the surface of almost all nucleated cells and play a crucial role in presenting antigens to CD8+ T cells (cytotoxic T cells). CD8+ T cells can only recognize antigens bound to MHC-I molecules, which are mostly endogenous cellular antigens. In contrast, MHC-II molecules are more limited in distribution and are mainly expressed on antigen-presenting cells such as B cells, monocytes-macrophages, and dendritic cells. The primary function of MHC-II molecules is to present processed antigen fragments to CD4+ T cells, predominantly participating in the presentation of exogenous antigens during the initiation of immune responses.
The T cell receptor (TCR) expressed on T cells can specifically recognize complexes of MHC molecules and peptide fragments and bind to them, which is closely related to immune responses and disease resistance. For example, cytotoxic T lymphocytes (CTLs) with antigen-specificity mainly recognize endogenous antigen peptides bound to MHC-I molecules. Cytotoxic T lymphocytes (CTLs) recognize and bind specific antigenic epitopes presented within the peptide-binding groove of MHC class I molecules on the surface of target cells through their T cell receptors (TCRs). With the assistance of co-stimulatory signals, CTLs are activated, proliferate, and form epitope-specific T cell clones. Activated CTLs then engage target cells through the same mechanism to exert their physiological effects.
Download our MHC product brochure
Download our MHC product brochure

Download our MHC product brochure

Based on the principle of TCR recognition of MHC-peptide complexes, various related drugs have been developed, including TCR-T cell therapy, TCR protein drugs, TCR-like antibodies, and others. To better support MHC-related research, ACROBiosystems relies on their mature protein structure design platform alongside their eukaryotic protein expression technology platform to avoid any prokaryotic refolding process instabilities, incorrect complex conformations, and other issues. Using these platforms, we successfully developed a series of natural MHC complexes with high biological activity in both monomer, tetramer forms with various fluorescent labels available. This includes targets such as NY-ESO-1, WT-1, GP100, GPC, and many others. Furthermore, to meet the diverse needs of our customers, we also offer custom MHC-peptide complex development services using our technology platforms to ensure natural conformation according to your specific needs and applications.
For fluorescently labeled Peptide-MHC tetramers, we offer flexible product formats. In addition to pre-assembled ready-to-use tetramers, you can also easily assemble the desired MHC-peptide complexes by using fluorescently labeled Streptavidin with peptide-free monomers.

Click to Customize

Background

The core function of the immune system is to identify self, eliminate non-self, maintain normal physiological activities, and prevent invasion by exogenous pathogens. This function is largely mediated by Major Histocompatibility Complex (MHC) molecules, also known as Human Leukocyte Antigen (HLA) in humans. MHC molecules are primarily divided into two classes: MHC-I and MHC-II. MHC-I molecules are found on the surface of almost all nucleated cells and play a crucial role in presenting antigens to CD8+ T cells (cytotoxic T cells). CD8+ T cells can only recognize antigens bound to MHC-I molecules, which are mostly endogenous cellular antigens. In contrast, MHC-II molecules are more limited in distribution and are mainly expressed on antigen-presenting cells such as B cells, monocytes-macrophages, and dendritic cells. The primary function of MHC-II molecules is to present processed antigen fragments to CD4+ T cells, predominantly participating in the presentation of exogenous antigens during the initiation of immune responses.
The T cell receptor (TCR) expressed on T cells can specifically recognize complexes of MHC molecules and peptide fragments and bind to them, which is closely related to immune responses and disease resistance. For example, cytotoxic T lymphocytes (CTLs) with antigen-specificity mainly recognize endogenous antigen peptides bound to MHC-I molecules. Cytotoxic T lymphocytes (CTLs) recognize and bind specific antigenic epitopes presented within the peptide-binding groove of MHC class I molecules on the surface of target cells through their T cell receptors (TCRs). With the assistance of co-stimulatory signals, CTLs are activated, proliferate, and form epitope-specific T cell clones. Activated CTLs then engage target cells through the same mechanism to exert their physiological effects.
Download our MHC product brochure
Download our MHC product brochure

Download our MHC product brochure

Based on the principle of TCR recognition of MHC-peptide complexes, various related drugs have been developed, including TCR-T cell therapy, TCR protein drugs, TCR-like antibodies, and others. To better support MHC-related research, ACROBiosystems relies on their mature protein structure design platform alongside their eukaryotic protein expression technology platform to avoid any prokaryotic refolding process instabilities, incorrect complex conformations, and other issues. Using these platforms, we successfully developed a series of natural MHC complexes with high biological activity in both monomer, tetramer forms with various fluorescent labels available. This includes targets such as NY-ESO-1, WT-1, GP100, GPC, and many others. Furthermore, to meet the diverse needs of our customers, we also offer custom MHC-peptide complex development services using our technology platforms to ensure natural conformation according to your specific needs and applications.
For fluorescently labeled Peptide-MHC tetramers, we offer flexible product formats. In addition to pre-assembled ready-to-use tetramers, you can also easily assemble the desired MHC-peptide complexes by using fluorescently labeled Streptavidin with peptide-free monomers.

Click to Customize

Service Features

Eukaryotic expression platform for a eukaryotic-based conformation

Professional MHC-peptide complex R&D technology platform

Various types of MHC I and antigens are available

Mature bioactivity verification platform: SPR/ELISA/FACS and more

Co-expression of heterodimer results in a more natural conformation

Monomer/Tetramer forms

FITC/PE/APC/Biotin-labeled are optional

Hot Applications of MHC-peptide Complex

Early Discovery
Early Discovery
Antigen epitope screening and validation
Specific CTL detection and analysis
TCR development and optimization
CMC Manufacturing and Quality Control
CMC Manufacturing and Quality Control
TCR development and optimization
Evaluation of specific T cell quantity, potency, and specificity
Preclinical & Clinical Research
Preclinical & Clinical Research
T-cell immune monitoring
Assessment of vaccine efficacy

Service Features

Eukaryotic expression platform for a eukaryotic-based conformation

Professional MHC-peptide complex R&D technology platform

Various types of MHC I and antigens are available

Mature bioactivity verification platform: SPR/ELISA/FACS and more

Co-expression of heterodimer results in a more natural conformation

Monomer/Tetramer forms

FITC/PE/APC/Biotin-labeled are optional

Hot Applications of MHC-peptide Complex

Early Discovery
Early Discovery
Antigen epitope screening and validation
Specific CTL detection and analysis
TCR development and optimization
CMC Manufacturing and Quality Control
CMC Manufacturing and Quality Control
TCR development and optimization
Evaluation of specific T cell quantity, potency, and specificity
Preclinical & Clinical Research
Preclinical & Clinical Research
T-cell immune monitoring
Assessment of vaccine efficacy

Service Features

Eukaryotic expression platform for a eukaryotic-based conformation

Professional MHC-peptide complex R&D technology platform

Various types of MHC I and antigens are available

Mature bioactivity verification platform: SPR/ELISA/FACS and more

Co-expression of heterodimer results in a more natural conformation

Monomer/Tetramer forms

FITC/PE/APC/Biotin-labeled are optional

Hot Applications of MHC-peptide Complex

Early Discovery
Early Discovery
Antigen epitope screening and validation
Specific CTL detection and analysis
TCR development and optimization
CMC Manufacturing and Quality Control
CMC Manufacturing and Quality Control
TCR development and optimization
Evaluation of specific T cell quantity, potency, and specificity
Preclinical & Clinical Research
Preclinical & Clinical Research
T-cell immune monitoring
Assessment of vaccine efficacy

Service Features

Eukaryotic expression platform for a eukaryotic-based conformation

Professional MHC-peptide complex R&D technology platform

Various types of MHC I and antigens are available

Mature bioactivity verification platform: SPR/ELISA/FACS and more

Co-expression of heterodimer results in a more natural conformation

Monomer/Tetramer forms

FITC/PE/APC/Biotin-labeled are optional

Hot Applications of MHC-peptide Complex

Early Discovery
Early Discovery
Antigen epitope screening and validation
Specific CTL detection and analysis
TCR development and optimization
CMC Manufacturing and Quality Control
CMC Manufacturing and Quality Control
TCR development and optimization
Evaluation of specific T cell quantity, potency, and specificity
Preclinical & Clinical Research
Preclinical & Clinical Research
T-cell immune monitoring
Assessment of vaccine efficacy

Service Features

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