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GUCY2C

GUCY2C信息

英文名称:Heat-stable enterotoxin receptor上市药物数量1
中文名称热稳定肠毒素受体临床药物数量8
靶点别称GUC2C，Intestinal guanylate cyclase，hSTAR，EC:4.6.1.2，EC 4.6.1，GC-C，GUCY2C，Guanylate Cyclase 2C，STA Receptor，Guanylyl Cyclase C，Guanylate Cyclase 2C (Heat Stable Enterotoxin Receptor)，Heat-Stable Enterotoxin Receptor，STAR，Heat Stable Enterotoxin Receptor，EC 4.6.1.2，DIAR6，MECIL，MUCIL最高研发阶段Approved
英文名称:Heat-stable enterotoxin receptor
中文名称热稳定肠毒素受体
靶点别称GUC2C，Intestinal guanylate cyclase，hSTAR，EC:4.6.1.2，EC 4.6.1，GC-C，GUCY2C，Guanylate Cyclase 2C，STA Receptor，Guanylyl Cyclase C，Guanylate Cyclase 2C (Heat Stable Enterotoxin Receptor)，Heat-Stable Enterotoxin Receptor，STAR，Heat Stable Enterotoxin Receptor，EC 4.6.1.2，DIAR6，MECIL，MUCIL
上市药物数量1
临床药物数量8
最高研发阶段Approved

GUCY2C产品列表

  • 属性

    Protein (21)Cell (1)

  • 产品库

    在线 (22)

  • 物种

    Human (15)Cynomolgus (3)Mouse (4)

  • 标签

    His Tag (13)Fc Tag (4)His Tag & Avi Tag (3)Fc Tag & Avi Tag (1)- (1)

  • 标记

    Unconjugated (7)FITC Labeled (3)Biotin-labeled (4)PE Labeled (2)AF488 Labeled (1)APC Labeled (2)AF647 Labeled (1)AF555 Labeled (1) (1)

共 22 项数据
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GUCY2C分子背景

GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer.

GUCY2C分子别名

GUCY2C,GUC2C,STAR,STA receptor,hSTAR,GC-C

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