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Siglec-3

Siglec-3信息

英文名称:Myeloid cell surface antigen CD33上市药物数量1
中文名称髓系细胞表面抗原CD33临床药物数量37
靶点别称Myeloid Cell Surface Antigen CD33，CD33 Molecule Transcript，CD33 Antigen，Siglec-3，P67，FLJ00391，Sialic acid-binding Ig-like lectin 3，CD33，CD33 Molecule，CD33 Antigen (Gp67)，SIGLEC3，Gp67，Sialic Acid Binding Ig-Like Lectin 3最高研发阶段Approved
英文名称:Myeloid cell surface antigen CD33
中文名称髓系细胞表面抗原CD33
靶点别称Myeloid Cell Surface Antigen CD33，CD33 Molecule Transcript，CD33 Antigen，Siglec-3，P67，FLJ00391，Sialic acid-binding Ig-like lectin 3，CD33，CD33 Molecule，CD33 Antigen (Gp67)，SIGLEC3，Gp67，Sialic Acid Binding Ig-Like Lectin 3
上市药物数量1
临床药物数量37
最高研发阶段Approved

Siglec-3产品列表

  • 属性

    Protein (17)Beads (1)

  • 产品库

    在线 (18)

  • 物种

    Human (15)Cynomolgus (1)Mouse (1)Rat (1)

  • 标签

    His Tag (9)Fc Tag (4)His Tag & Avi Tag (1)Llama IgG Fc Tag (2)- (1)Fc Tag & Avi Tag (1)

  • 标记

    Unconjugated (9)Biotin-labeled (2)FITC Labeled (2) (1)PE Labeled (2)AF647 Labeled (1)APC Labeled (1)

共 18 项数据
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Siglec-3分子背景

Myeloid cell surface antigen CD33 is also known as SIGLEC3, Siglecs (sialic acid binding Ig­like lectins) and GP67, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Human CD33 / Siglec-3 cDNA encodes a 364 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N-­terminal Ig-­like V­-type domain, one Ig­-like C2-­type domains, a transmembrane region and a cytoplasmic tail. CD33 / Siglec-3 usually considered myeloid-specific, but it can also be found on some lymphoid cells. In the immune response, CD33 / Siglec-3 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33 / Siglec-3 induces apoptosis in acute myeloid leukemia.

Siglec-3分子别名

CD33,SIGLEC3,gp67

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