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描述/背景（Background）
The Claudin-18.2 (CLDN 18.2) protein, an isoform of Claudin 18, a member of the tight junction protein family, is a highly selective biomarker with limited expression in normal tissues and often abnormal expression during the occurrence and development of various primary malignant tumors, such as gastric cancer/gastroesophageal junction (GC/GEJ) cancer, breast cancer, colon cancer, liver cancer, head and neck cancer, bronchial cancer and non-small-cell lung cancer. Claudin-18.2 participates in the proliferation, differentiation and migration of tumor cells. Recent studies have identified Claudin-18.2 expression as a potential specific marker for the diagnosis and treatment of these tumors.
种属（Host Species）
Mouse
克隆号（Clone）
3B10
适用方法（Application）
IHC
效价（Property）
1：1000
状态（State）
Liquid
阳性对照（Positive Control）
Human Stomach Tissues
克隆类型（Clonality）
Monoclonal
分子别名（Synonym）
Claudin18.2, CLDN 18.2
研究领域（Research Field）
Cancer Drug Targets
抗体来源（Source）
Mouse
同种型（Isotype）
IgG
储存（Storage）
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
质量管理控制体系（QMS）
产品展示
质控样本（Control Sample）
Immunohistochemical analysis of paraffin embedded human stomach tissue labelled with HCS-S278 at 1/1000 dilution.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
Immunohistochemical analysis of paraffin-embedded human lung tissue labeling Claudin-18.2 with HCS-S278 at 1/1000 dilution, followed by Goat Anti-Mouse IgG H&L (HRP) ready to use. The staining in the lung tissue sample was negative. Counter stained with Hematoxylin. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
肿瘤样本（Cancer Sample）
Immunohistochemical analysis of paraffin-embedded human cancer tissue labeling Claudin-18.2 with HCS-S278 at 1/1000 dilution, followed by Goat Anti-Mouse IgG H&L (HRP) ready to use. Membranous staining on tumor cells is observed. Counter stained with Hematoxylin. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
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