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Anti-SARS-CoV-2 Nucleocapsid Antibody, Human IgG1 (AS95) (MALS verified)

COAMS
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  • 抗体来源（Source）

    Anti-SARS-CoV-2 Nucleocapsid Antibody, Human IgG1 is isolated from a SARS-CoV-2 infected patient and is recombinantly produced from CHO cells. This monoclonal antibody is purified by Protein A affinity chromatography. As verified by binding test with N-NTD (Cat.No. NUN-C5143) and N-CTD (Cat.No. NUN-C5145) protein, this antibody can only bind to N-NTD (AA Gly 44 - Glu 174). ELISA test validated that this antibody can bind multiple N protein variants with similar affinity as compared to the wild type N protein (Cat.No. NUN-C5227).

  • 克隆号（Clone）

    AS95

  • 亚型（Isotype）

    Human IgG1 | Human Kappa

  • 偶联（Conjugate）

    Unconjugated

  • 抗体类型（Antibody Type）

    Recombinant Monoclonal

  • 种属反应性（Reactivity）

    Virus

  • 特异性（Specificity）

    This product can recognize SARS-CoV-2 Nucleocapsid protein. Cross-reactivity with Nucleocapsid protein of other coronaviruses has not been tested.

  • 应用（Application）

    Application
    Recommended Usage
    ELISA
    0.2-50 ng/mL

  • 纯度（Purity）

    95% as determined by SDS-PAGE.

    90% as determined by SEC-MALS.

  • 纯化（Purification）

    Protein A purified / Protein G purified

  • 制剂（Formulation）

    Supplied as 0.2 μm filtered solution in PBS, pH7.4 .

    Contact us for customized product form or formulation.

  • 运输（Shipping）

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • 存储（Storage）

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. For long term storage, the product is stable for up to 3 years at -70°C from date of receipt;
    2. For short term storage, the product is stable for up to 12 months at 2-8°C from date of receipt.

  • 质量管理控制体系（QMS）

    1. 质量管理体系（ISO, GMP）
    2. 质量优势
    3. 质控流程

产品展示

  • 电泳（SDS-PAGE）

    Nucleocapsid protein SDS-PAGE

    Anti-SARS-CoV-2 Nucleocapsid Antibody, Human IgG1 (AS95) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • SEC-MALS

    Nucleocapsid protein SEC-MALS

    The purity of Anti-SARS-CoV-2 Nucleocapsid Antibody, Human IgG1 (AS95) (Cat. No. NUN-CH14) is more than 90% and the molecular weight of this protein is around 130-160 kDa verified by SEC-MALS.

    Report

  • 活性（Bioactivity）-ELISA

    Nucleocapsid protein ELISA

    Immobilized SARS-CoV-2 (COVID-19) Nucleocapsid protein, His Tag (Cat. No. NUN-C5227) at 2μg/mL (100μL/well) can bind Anti-SARS-CoV-2 Nucleocapsid Antibody, Human IgG1 (AS95) (Cat. No. NUN-CH14) with a linear range of 0.2-6 ng/mL (Routinely tested).

    Protocol

  • Nucleocapsid protein ELISA

    Immobilized Anti-SARS-CoV-2 Nucleocapsid Antibody, Human IgG1 (AS95) (Cat. No. NUN-CH14) at 1μg/mL (100μL/well) can bind SARS-CoV-2 Nucleocapsid protein, His Tag (B.1.1.529/Omicron) (Cat. No. NUN-C52Ht) with a linear range of 0.4-6 ng/mL (Routinely tested).

    Protocol

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背景介绍

Nucleocapsid (N) protein is the most abundant protein found in coronavirus. CoV N protein is a highly immunogenic phosphoprotein important for viral genome replication and modulation of cell signaling pathways. It was first identified by a research team while they were screening for ADP-ribosylated proteins during coronavirus (CoV) infection (Grunewald M. E., et al. 2017, Virology; 517: 62-68). The array of diverse functional activities accommodated in N protein makes it more than a structural protein but also an interesting target in the development of antiviral therapeutics. Because of the conservation of N protein sequence and its strong immunogenicity, N protein of coronavirus is chosen as a diagnostic tool.

前沿进展

 
药物研发进展
  • 英文全称：

    Nucleocapsid proteins

  • 中文全称：

    核壳蛋白

  • 种类：

  • 上市药物数量：

    0 详情

  • 临床药物数量：

    1 详情

  • 最高研发阶段：

    临床一期

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