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Monoclonal Anti-RSV-Pre-F0 specific Antibody, Human IgG1 (12C6) (MALS verified)

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  • 抗体来源（Source）

    Monoclonal Anti-RSV-Pre-F0 specific Antibody, Human IgG1 (12C6) is a chimeric monoclonal antibody recombinantly expressed from CHO, which combines the variable region of a mouse monoclonal antibody with Human constant domain.

  • 克隆号（Clone）

    12C6

  • 亚型（Isotype）

    Human IgG1 | Human Kappa

  • 偶联（Conjugate）

    Unconjugated

  • 抗体类型（Antibody Type）

    Recombinant Monoclonal

  • 种属反应性（Reactivity）

    Virus

  • 免疫原（Immunogen）

    Recombinant HRSV (A) Fusion glycoprotein F0 derived from human 293 cells.

  • 特异性（Specificity）

    This product is a specific antibody specifically reacts with Prefusion glycoprotein F0/pre-F protein (RSV).

  • 应用（Application）

    Application
    Recommended Usage
    ELISA
    0.2-625 ng/mL 

  • 纯化（Purification）

    Protein A purified / Protein G purified

  • 制剂（Formulation）

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法（Reconstitution）

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储（Storage）

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.

  • 质量管理控制体系（QMS）

    1. 质量管理体系（ISO, GMP）
    2. 质量优势
    3. 质控流程

产品展示

  • SEC-MALS

    Prefusion glycoprotein F0/pre-F protein (RSV) SEC-MALS

    The purity of Monoclonal Anti-RSV-Pre-F0 specific Antibody, Human IgG1 (12C6) (Cat. No. RS0-S286) is more than 95% and the molecular weight of this protein is around 135-165 kDa verified by SEC-MALS.

    Report

  • 活性（Bioactivity）-ELISA

    Prefusion glycoprotein F0/pre-F protein (RSV) ELISA

    Immobilized HRSV (A) Pre-fusion glycoprotein F0, His Tag (Cat. No. RSF-V52H7) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-RSV-Pre-F0 specific Antibody, Human IgG1 (12C6) (Cat. No. RS0-S286) with a linear range of 0.2-2 ng/mL. HRSV (A) Post-fusion glycoprotein F0, His Tag (Cat. No. RSF-V52H6) is verified not recoginized by Monoclonal Anti-RSV-Pre-F0 specific Antibody, Human IgG1 (12C6) (Cat. No. RS0-S286) in low concentration (QC tested).

    Protocol

  • Prefusion glycoprotein F0/pre-F protein (RSV) ELISA

    Immobilized HRSV (A) Pre-fusion glycoprotein F0, His Tag (Cat. No. RSF-V52H7) at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-RSV-Pre-F0 specific Antibody, Human IgG1 (12C6) (Cat. No. RS0-S286), Anti-Fusion glycoprotein F0 Antibody, Human IgG1 (D25) with a linear range of 0.1-2 ng/mL. HRSV (A) Post-fusion glycoprotein F0, His Tag (Cat. No. RSF-V52H6) is verified not recoginized by Monoclonal Anti-RSV-Pre-F0 specific Antibody, Human IgG1 (12C6) (Cat. No. RS0-S286)/Anti-Fusion glycoprotein F0 Antibody, Human IgG1 (D25) in low concentration (Routinely tested).

    Protocol

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背景介绍

Human respiratory syncytial virus (HRSV) is the most common etiological agent of acute lower respiratory tract disease in infants and can cause repeated infections throughout life. The RSV fusion glycoprotein (RSV F) is the principal target of RSV neutralizing antibodies in human sera. The RSV F is a type I viral fusion protein synthesized as inactive, single-chain polypeptides that assemble into trimers. RSV F fuses the viral and host cell membranes by irreversible protein refolding from the labile prefusion conformation to the stable post-fusion conformation.

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