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Mouse Cadherin-17 / CDH17 Protein, His Tag (MALS verified)

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  • 分子别名(Synonym)

    Cadherin-17,CDH17,HPT-1,LI-cadherin

  • 表达区间及表达系统(Source)

    Mouse Cadherin-17, His Tag (CA7-M52H5) is expressed from human 293 cells (HEK293). It contains AA Phe 26 - Met 786 (Accession # Q9R100-1).

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    Cadherin-17 Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 86.3 kDa. The protein migrates as 95-110 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 偶联(Conjugate)

    Unconjugated

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method.

  • 纯度(Purity)

    90% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in 20 mM Tris, 150 mM NaCl, pH8.0 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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  • 电泳(SDS-PAGE)

    Cadherin-17 SDS-PAGE

    Mouse Cadherin-17, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    Cadherin-17 SEC-MALS

    The purity of Mouse Cadherin-17, His Tag (Cat. No. CA7-M52H5) is more than 85% and the molecular weight of this protein is around 85-125 kDa verified by SEC-MALS.

    Report
  • 活性(Bioactivity)-ELISA

     Cadherin-17 ELISA

    Immobilized Mouse Cadherin-17, His Tag (Cat. No. CA7-M52H5) at 1 μg/mL (100 μL/well) can bind various dilution ratio of Anti-Cadherin 17 (QC tested).

    Protocol

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背景介绍

Cadherin-17, also known as liver-intestine (LI) Cadherin, belongs to the cadherin family of calcium-dependent cell adhesion molecules. In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.

前沿进展

 
药物研发进展
  • 英文全称:

    Cadherin-17

  • 中文全称:

    钙粘蛋白17

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    6 详情

  • 最高研发阶段:

    临床二期

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