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Cynomolgus CD39 Protein, His Tag (active enzyme, MALS verified)

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  • 分子别名（Synonym）

    CD39,ENTPD1,NTPDase 1,Entpd1,Ecto-ATPDase 1,Ecto-ATPase 1

  • 表达区间及表达系统（Source）

    Cynomolgus CD39 Protein, His Tag (CD9-C5PH3) is expressed from CHO cells. It contains AA Thr 60 - Val 500 (Accession # XP_015311944.1).

    Request for sequence

  • 蛋白结构（Molecular Characterization）

    CD39 Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 52.3 kDa. The protein migrates as 65-80 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 偶联（Conjugate）

    Unconjugated

  • 内毒素（Endotoxin）

    Less than 1.0 EU per μg by the LAL method.

  • 纯度（Purity）

    95% as determined by SDS-PAGE.

  • 制剂（Formulation）

    Supplied as 0.2 μm filtered solution in 20 mM Tris, 150 mM NaCl, 20% Glycerol, pH8.0 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 运输（Shipping）

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • 存储（Storage）

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 3 months under sterile conditions.

  • 质量管理控制体系（QMS）

    1. 质量管理体系（ISO, GMP）
    2. 质量优势
    3. 质控流程

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  • 电泳（SDS-PAGE）

    CD39 SDS-PAGE

    Cynomolgus CD39 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    CD39 SEC-MALS

    The purity of Cynomolgus CD39 Protein, His Tag (Cat. No. CD9-C5PH3) is more than 85% and the molecular weight of this protein is around 65-85 kDa verified by SEC-MALS.

    Report

  • 活性（Bioactivity）-ELISA

    CD39 ELISA

    Immobilized Anti-CD39 Antibody, Human IgG1 at 1 μg/mL (100 μL/well) can bind Cynomolgus CD39 Protein, His Tag (Cat. No. CD9-C5PH3) with a linear range of 5-78 ng/mL (QC tested).

    Protocol

  • CD39 ELISA

    Immobilized Cynomolgus CD39 Protein, His Tag (Cat. No. CD9-C5PH3) at 1 μg/mL (100 μL/well) can bind Anti-CD39 Antibody, Human IgG1 with a linear range of 0.03-1 ng/mL (Routinely tested).

    Protocol

  • 活性（Bioactivity）

    Measured by its ability to hydrolyze the 5’-phosphate group from the substrate adenosine-5’-triphosphate (ATP). The specific activity is > 15,000 pmol/min/μg (QC tested).

    Protocol

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背景介绍

CD39 is also known as Ectonucleoside triphosphate diphosphohydrolase 1, ENTPD1, NTPDase 1, Ecto-ATPDase 1, in the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. NTPDase-1 was originally described as CD39, a B lymphocyte cell surface marker, but it is also present on the surface of natural killer cells, T cells, and some endothelial cells.Regulatory T cells(Tregs) mediate immunosuppression through multiple, non-redundant, cell-contact dependent and independent mechanisms, a growing body of evidence suggests an important role for the CD39-CD73-adenosine pathway. CD39 ectonucleotidase is the rate-limiting enzyme of a cascade leading to the generation of suppressive adenosine that alters CD4 and CD8 T cell and natural killer cell antitumor activities.

前沿进展

 
药物研发进展
  • 英文全称：

    Ectonucleoside triphosphate diphosphohydrolase 1

  • 中文全称：

    外核苷三磷酸二磷酸水解酶-1

  • 种类：

  • 上市药物数量：

    0 详情

  • 临床药物数量：

    10 详情

  • 最高研发阶段：

    临床二期

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