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Human GCGR / Glucagon receptor Full Length Protein (VLP)

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产品详情

  • 分子别名（Synonym）

    Glucagon R, GCGR,Glucagon receptor

  • 表达区间及表达系统（Source）

    Human GCGR Full Length Protein (VLP) (GCR-H52P5) is expressed from human 293 cells (HEK293). It contains AA Ala 26 - Asn 432 (Accession # P47871-1).

    Predicted N-terminus: Asp

  • 蛋白结构（Molecular Characterization）

    Virus-like particles(VLPs) are formed by self-assembly of envelop/capsid proteins from viruses. Membrane Proteins can be constituted in-situ with VLPs produced from HEK293 cell cultures. These VLPs concentrate conformationally intact membrane proteins directly on the cell surface and produce soluble, high-concentration proteins perfect for immunization and antibody screening.

    The VLPs provide the display of properly folded membrane proteins in their native cellular membrane in a compact size of 100~300 nm diameter (similar to the size of most viruses) making it optimal targets for dendritic cells in vivo and surface attachment for phage display.

  • 偶联（Conjugate）

    Unconjugated

  • 内毒素（Endotoxin）

    Less than 1.0 EU per μg by the LAL method.

  • 制剂（Formulation）

    The VLPs are highly immunogenic, so the immunization strategy should be optimized (antigen dose, regimen and adjuvant).

    Supplied as 0.2 μm filtered solution in PBS, Arginine, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 运输（Shipping）

    This product is supplied and shipped with dry ice, please inquire the shipping cost.

  • 存储（Storage）

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 12 months under sterile conditions.

  • 质量管理控制体系（QMS）

    1. 质量管理体系（ISO, GMP）
    2. 质量优势
    3. 质控流程
  • *The isotype control of empty/mock VLP (Cat. No. VLP-N5213) is sold separately and not included in protein, you can follow this link for product information.

数据展示

  • 活性（Bioactivity）-ELISA

    GCGR ELISA

    Immobilized Human GCGR Full Length Protein (VLP) (Cat. No. GCR-H52P5) at 5 μg/mL (100 μL/well) can bind Monoclonal Anti-Human GCGR antibody, Human IgG4 (Crotedumab) with a linear range of 0.1-20 ng/mL (QC tested).

    Protocol

  • GCGR ELISA

    Immobilized Human GCGR Full Length Protein (VLP) (Cat. No. GCR-H52P5) at 5 μg/mL (100 μL/well) can bind Monoclonal Anti-Human GCGR antibody, Human IgG2 (Volagidemab) with a linear range of 0.1-20 ng/mL (Routinely tested).

    Protocol

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背景介绍

The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of  type 2 diabetes mellitus (T2DM) . The ever increasing prevalence of type 2 diabetes mellitus in the developed and developing nations calls for the introduction of new and more effective treatments. Glucagon receptor (GCGR) antagonists are highly validated in preclinical models of T2DM and thus have the potential to be developed as a new therapy.

前沿进展

 
药物研发进展
  • 英文全称：

    Glucagon receptor

  • 中文全称：

    胰高血糖素受体

  • 种类：

  • 上市药物数量：

    5 详情

  • 临床药物数量：

    30 详情

  • 最高研发阶段：

    批准上市

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