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APC-Labeled Human Her2 / ErbB2 Protein, His Tag (Site-specific conjugation)

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  • 分子别名（Synonym）

    ERBB2,CD340,HER-2,neu,HER2,MLN19,NEU,NGL,TKR1

  • 表达区间及表达系统（Source）

    APC-Labeled Human Her2, His Tag (HE2-HA2H7) is produced via conjugation of APC to Human Her2, His Tag with a new generation site-specific technology under optimal conditions with a proprietary technology. Human Her2, His Tag is expressed from human 293 cells (HEK293). It contains AA Thr 23 - Thr 652 (Accession # P04626-1).

    Predicted N-terminus: Thr 23

    Request for sequence

  • 蛋白结构（Molecular Characterization）

    Her2 Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 73.0 kDa.

  • 偶联（Conjugate）

    APC

    Excitation Wavelength: 640 nm

    Emission Wavelength: 661 nm

  • 应用说明（Application）

    Please note that this product is NOT compatible to streptavidin detection system.

  • 制剂（Formulation）

    Lyophilized from 0.22 μm filtered solution in PBS, 0.5% BSA, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法（Reconstitution）

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储（Storage）

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.

  • 质量管理控制体系（QMS）

    1. 质量管理体系（ISO, GMP）
    2. 质量优势
    3. 质控流程

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  • 活性（Bioactivity）-FACS

    Her2 FACS

    5e5 of anti-Her2 CAR-293 cells were stained with 100 μL of 1:25 dilution (4 μL stock solution in 100 μL FACS buffer) of APC-Labeled Human Her2, His Tag (Cat. No. HE2-HA2H7) and negative control protein respectively. APC signal was used to evaluate the binding activity (QC tested).

    Protocol

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背景介绍

Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2,HER-2 /neu, NEU, NGL,TKR1 and c-erb B2,and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30% of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer, communication at the neuromuscular junction and regulation of cell growth and differentiation .

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药物研发进展
  • 英文全称：

    Receptor protein-tyrosine kinase erbB-2

  • 中文全称：

    受体蛋白酪氨酸激酶 erbB-2

  • 种类：

  • 上市药物数量：

    39 详情

  • 临床药物数量：

    201 详情

  • 最高研发阶段：

    批准上市

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