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Canine IL-13 Protein, His Tag

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  • 分子别名（Synonym）

    IL13,ALRH,BHR1,MGC116786,MGC116788,MGC116789,P600,Interleukin-13

  • 表达区间及表达系统（Source）

    Canine IL-13, His Tag (IL3-C52H4) is expressed from human 293 cells (HEK293). It contains AA Ser 19 - Arg 131 (Accession # NP_001003384.1).

    Predicted N-terminus: Ser 19

    Request for sequence

  • 蛋白结构（Molecular Characterization）

    IL-13 Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 14.3 kDa. The protein migrates as 30-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 内毒素（Endotoxin）

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • 纯度（Purity）

    >90% as determined by SDS-PAGE.

  • 制剂（Formulation）

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法（Reconstitution）

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储（Storage）

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.

  • 质量管理控制体系（QMS）

    1. 质量管理体系（ISO, GMP）
    2. 质量优势
    3. 质控流程

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数据展示

  • 电泳（SDS-PAGE）

    IL-13 SDS-PAGE

    Canine IL-13, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

  • 活性（Bioactivity）-ELISA

    IL-13 ELISA

    Immobilized Canine IL-13, His Tag (Cat. No. IL3-C52H4) at 5 μg/mL (100 μL/well) can bind Human IL-13RA2, Fc Tag (MALS verified) (Cat. No. IL2-H5256) with a linear range of 5-39 ng/mL (QC tested).

    Protocol

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背景介绍

Interleukin 13 (IL13) is also known as ALRH, BHR1and P600, is a single-chain glycosylated polypeptide, and is a cytokine critical in regulating inflammatory and immune responses. IL13 is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains. The functions of IL-13 overlap considerably with those of IL-4, especially with regard to changes induced on hematopoietic cells, but these effects are probably less important given the more potent role of IL-4. IL-13 induces matrix metalloproteinases (MMPs) as part of a mechanism that protects against excessive allergic inflammation that predisposes to asphyxiation. IL-13 induces many features of allergic lung disease, including airway hyperresponsiveness, goblet cell metaplasia and mucus hypersecretion, which all contribute to airway obstruction.

前沿进展

 
药物研发进展
  • 英文全称：

    Interleukin-13

  • 中文全称：

    白细胞介素-13

  • 种类：

  • 上市药物数量：

    3 详情

  • 临床药物数量：

    14 详情

  • 最高研发阶段：

    批准上市

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