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Mouse IL-6 R alpha / CD126 Protein, Fc Tag (MALS verified)

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  • 分子别名(Synonym)

    IL6R,CD126,IL-6R-1,IL-6RA,IL6RA,IL-6R-alpha,IL6RQ,gp80

  • 表达区间及表达系统(Source)

    Mouse IL-6 R alpha Protein, Fc Tag (ILR-M5255) is expressed from human 293 cells (HEK293). It contains AA Leu 20 - Glu 357 (Accession # P22272-1).

    Predicted N-terminus: Leu 20

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    IL-6 R alpha Structure

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 63.9 kDa. The protein migrates as 70-90 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 偶联(Conjugate)

    Unconjugated

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method.

  • 纯度(Purity)

    90% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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  • 电泳(SDS-PAGE)

    IL-6 R alpha SDS-PAGE

    Mouse IL-6 R alpha Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    IL-6 R alpha SEC-MALS

    The purity of Mouse IL-6 R alpha Protein, Fc Tag (Cat. No. ILR-M5255) is more than 85% and the molecular weight of this protein is around 145-175 kDa verified by SEC-MALS.

    Report
  • 活性(Bioactivity)-ELISA

     IL-6 R alpha ELISA

    Immobilized Mouse IL-6, His Tag (Cat. No. IL6-M5245) at 5 μg/mL (100 μL/well) can bind Mouse IL-6 R alpha Protein, Fc Tag (Cat. No. ILR-M5255) with a linear range of 1-10 ng/mL (QC tested).

    Protocol

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背景介绍

Interleukin 6 receptor (IL6R) is also known as CD126 (Cluster of Differentiation 126) , is a potent pleiotropic cytokine that regulates cell growth and differentiation of various tissues, and is known particularly for its role in the immune response and acute phase reactions. IL6R is a protein complex consisting of a IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. IL6R also denotes the human gene encoding this subunit. Alternatively spliced transcript variants encoding distinct isoforms have been reported. IL6R subunit also shared by many other cytokines. The soluble form of IL6R arises from proteolytic cleavage of membrane-bound IL6Rα, and acts agonistically by making the IL6 ligand accessible to the signal transducer gp130. Dysregulated production of IL6 and IL6R are implicated in the pathogenesis of several inflammatory diseases and malignancies such as multiple myeloma, rheumatoid arthritis, or osteoporosis, and it has been reported that a humanized anti-IL6R monoclonal antibody is a promising agent applicable to the therapeutic approach for IL6 driven diseases. Interleukin-6 receptor has been shown to interact with Interleukin 6 and Ciliary neurotrophic factor.

前沿进展

 
药物研发进展
  • 英文全称:

    Interleukin-6 receptor alpha subunit

  • 中文全称:

    白细胞介素-6受体α亚基

  • 种类:

  • 上市药物数量:

    7 详情

  • 临床药物数量:

    13 详情

  • 最高研发阶段:

    批准上市

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