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PE-Labeled Human SLAMF7 / CRACC / CD319 Protein, His Tag (Site-specific conjugation)

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  • 分子别名(Synonym)

    SLAMF7,CD319,CS1,CRACC,19A,FOAP-12

  • 表达区间及表达系统(Source)

    PE-Labeled Human SLAMF7, His Tag (SL7-HP2H3) is produced via site-specific conjugation of PE to Human SLAMF7, His Tag under optimal conditions with a proprietary technology. Human SLAMF7, His Tag is expressed from human 293 cells (HEK293). It contains AA Ser 23 - Met 226 (Accession # Q9NQ25-1).

    Predicted N-terminus: Ser 23

    Request for sequence

  • 蛋白结构(Molecular Characterization)

    SLAMF7 Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 25.6 kDa.

  • 偶联(Conjugate)

    PE

    Excitation Wavelength: 488 nm / 561 nm

    Emission Wavelength: 575 nm

  • 应用说明(Application)

    Evaluation of anti-SLAMF7 CAR expression by flow cytometry. Please note that this product is NOT compatible to streptavidin detection system.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, 0.5% BSA, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

数据展示

  • 活性(Bioactivity)-FACS

     SLAMF7 FACS

    1e6 of the anti-SLAMF7 CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of PE-Labeled Human SLAMF7, His Tag (Cat. No. SL7-HP2H3) and negative control protein respectively, PE signals was used to evaluate the binding activity (QC tested).

    Protocol

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背景介绍

SLAM family member 7 (SLAMF7) is also known as CD2-like receptor-activating cytotoxic cells (CRACC), Membrane protein FOAP-12, CD antigen CD319, Novel Ly9, Protein 19A, which is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Isoform 1 of SLAMF7 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. May play a role in lymphocyte adhesion. Isoform 3 of SLAMF7 does not mediate any NK cell activation.

前沿进展

 
药物研发进展
  • 英文全称:

    SLAM family member 7

  • 中文全称:

    SLAM家族成员-7

  • 种类:

  • 上市药物数量:

    1 详情

  • 临床药物数量:

    6 详情

  • 最高研发阶段:

    批准上市

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