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Integrin alpha 4 beta 7

Integrin alpha 4 beta 7信息

英文名称:Integrin alpha-4/beta-7上市药物数量4
中文名称整合素α-4/β-7复合体临床药物数量12
靶点别称LPAM-1，Lymphocyte Peyer's patch Adhesion Molecule 1最高研发阶段Approved
英文名称:Integrin alpha-4/beta-7
中文名称整合素α-4/β-7复合体
靶点别称LPAM-1，Lymphocyte Peyer's patch Adhesion Molecule 1
上市药物数量4
临床药物数量12
最高研发阶段Approved

Integrin alpha 4 beta 7产品列表

  • 属性

    Protein (2)Kits (1)

  • 产品库

    在线 (3)

  • 物种

    Human (2)Cynomolgus (1)

  • 标签

    His Tag (2)- (1)

  • 标记

    Unconjugated (2) (1)

共 3 项数据
  • 1

Integrin alpha 4 beta 7分子背景

Integrin alpha 4 beta 7 is an integrin family adhesion receptor that shares subunits with alpha 4 beta 1 (VLA4) and the E-Cadherin receptor, alpha E beta 7 . Integrin alpha 4 beta 7, which is critical for homing to intestinal mucosa, is induced during T cell activation in Peyer’s patches or mesenteric lymph nodes.Its expression requires signals from local dendritic and stromal cells, including secreted retinoic acid. The HIV-1 envelope protein gp120 binds to the active form of Integrin alpha 4 beta 7, and this may or may not account for the concentration of HIV-1 virus in the gut-associated lymphoid tissue (GALT). Integrin alpha 4 beta 7 may also be involved in lymphocyte trafficking in acute intestinal graft vs. host disease (GVHD).

Integrin alpha 4 beta 7分子别名

Integrin alpha 4 beta 7,ITGA4&ITGB7

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