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Mouse IL-21 Protein, His Tag

COAMS
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IL1-M52H3-100ug
¥3675.00
IL1-M52H3-1mg (500ug X 2)
¥24255.00
合计0件 产品金额¥ 0
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产品详情

  • 分子别名（Synonym）

    IL21,Za11,Interleukin-21

  • 表达区间及表达系统（Source）

    Mouse IL-21 Protein, His Tag (IL1-M52H3) is expressed from human 293 cells (HEK293). It contains AA Pro 25 - Ser 146 (Accession # Q9ES17).

    Predicted N-terminus: Pro 25

    Request for sequence

  • 蛋白结构（Molecular Characterization）

    IL-21 Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 16.3 kDa. The protein migrates as 20 kDa and 23-28 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 偶联（Conjugate）

    Unconjugated

  • 内毒素（Endotoxin）

    Less than 1.0 EU per μg by the LAL method.

  • 纯度（Purity）

    90% as determined by SDS-PAGE.

  • 制剂（Formulation）

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法（Reconstitution）

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储（Storage）

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.

  • 质量管理控制体系（QMS）

    1. 质量管理体系（ISO, GMP）
    2. 质量优势
    3. 质控流程

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  • 电泳（SDS-PAGE）

    IL-21 SDS-PAGE

    Mouse IL-21 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • 活性（Bioactivity）-ELISA

    IL-21 ELISA

    Immobilized Mouse IL-21 Protein, His Tag (Cat. No. IL1-M52H3) at 5 μg/mL (100 μL/well) can bind Biotinylated Mouse IL-21 R Protein, His,Avitag (Cat. No. ILR-M82E3) with a linear range of 0.3-20 ng/mL (QC tested).

    Protocol

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背景介绍

Interleukin-21 (IL-21) is a secreted protein which belongs to the IL-15 / IL-21 family. Interleukin-21 / IL-21 belongs to a family of cytokines that bind to a composite receptor consisting of a private receptor (IL21R) and the common cytokine receptor gamma chain (gamma(C)). Interleukin-21 / IL-21 impacts a number of cell types, including CD8+ memory T cells, NK cells and subsets of CD4 memory T cells. The IL-21R is widely distributed on lympho-haematopoietic cells. IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the γ chain (γc) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3.

前沿进展

 
药物研发进展
  • 英文全称：

    Interleukin-21

  • 中文全称：

    白细胞介素-21

  • 种类：

  • 上市药物数量：

    0 详情

  • 临床药物数量：

    3 详情

  • 最高研发阶段：

    临床二期

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