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Canine IL-17A / CTLA-8 Protein, His Tag

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ILA-C52H7-100ug
¥3990.00
ILA-C52H7-1mg
¥26670.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    IL-17A,Interleukin-17A,CTLA-8,IL-17

  • 表达区间及表达系统(Source)

    Canine IL-17A, His Tag (ILA-C52H7) is expressed from human 293 cells (HEK293). It contains AA Gly 26 - Ala 155 (Accession # C6L8D7-1).

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    IL-17A Structure

    This protein carries a polyhistidine tag at the N-terminus.

    The protein has a calculated MW of 17.0 kDa. The protein migrates as 18 kDa and 22 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 偶联(Conjugate)

    Unconjugated

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method.

  • 纯度(Purity)

    90% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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  • 电泳(SDS-PAGE)

    IL-17A SDS-PAGE

    Canine IL-17A, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

  • 活性(Bioactivity)-ELISA

     IL-17A ELISA

    Immobilized Monoclonal Anti-Human IL17A Antibody, Human IgG1 at 2 μg/mL (100 μL/well) can bind Canine IL-17A, His Tag (Cat. No. ILA-C52H7) with a linear range of 5-39 ng/mL (QC tested).

    Protocol
  •  IL-17A ELISA

    Immobilized Canine IL-17A, His Tag (Cat. No. ILA-C52H7) at 2 μg/mL (100 μL/well) can bind Human IL-17 RC, Fc Tag (Cat. No. ILC-H5259) with a linear range of 4-63 ng/mL (Routinely tested).

    Protocol
  •  IL-17A ELISA

    Immobilized Canine IL-17A, His Tag (Cat. No. ILA-C52H7) at 2 μg/mL (100 μL/well) can bind Human IL-17 RA, Fc Tag (MALS verified) with a linear range of 0.1-4 ng/mL (Routinely tested).

    Protocol

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背景介绍

Interleukin-17A (IL17A) is also known as cytotoxic T-lymphocyte-associated antigen 8 (CTLA8),which is a proinflammatory cytokine produced by activated T cells. IL17A can regulate the activities of NF-kappaB and mitogen-activated protein kinases. Also,IL17A can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO).Furthermore,IL17A has been found both in glycosylated and nonglycosylated forms. High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

前沿进展

 
药物研发进展
  • 英文全称:

    Interleukin 17A

  • 中文全称:

    白细胞介素-17A

  • 种类:

  • 上市药物数量:

    5 详情

  • 临床药物数量:

    28 详情

  • 最高研发阶段:

    批准上市

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