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Product Details
Synonym
APRIL, TNFSF13, TALL-2, TRDL-1, CD256, TALL2, ZTNF2
Source
Human APRIL Protein, Fc Tag (APL-H5363) is expressed from CHO cells. It contains AA Gln 111 - Leu 250 (Accession # O75888-1).
Predicted N-terminus: Pro
Request for sequenceMolecular Characterization
Other Tags and Version Biotin & Other Labeled Version
This protein carries a human IgG1 Fc tag at the N-terminus.
The protein has a calculated MW of 42.2 kDa. The protein migrates as 45-55 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
The protein is designed as a trimer.
Endotoxin
Less than 0.01 EU per μg by the LAL method / rFC method.
Purity
>90% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
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Performance Data
SDS-PAGE
Human APRIL Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).
SEC-MALS
The purity of Human APRIL Protein, Fc Tag (Cat. No. APL-H5363) is more than 90% and the molecular weight of this protein is around 250-290 kDa verified by SEC-MALS.
Report
Bioactivity-ELISA
Immobilized Human BCMA, Mouse IgG2a Fc Tag (Cat. No. BCA-H5253) at 5 μg/mL (100 μL/well) can bind Human APRIL Protein, Fc Tag (Cat. No. APL-H5363) with a linear range of 0.1-2 ng/mL (QC tested).
Protocol
Immobilized Human APRIL Protein, Fc Tag (Cat. No. APL-H5363) at 2 μg/mL (100 μL/well) can bind Biotinylated Human TACI, Fc,Avitag (Cat. No. TAI-H82F6) with a linear range of 0.2-16 ng/mL (Routinely tested).
Protocol
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Background
Recent Advances
Drug Development Progress- English Name：
Tumor necrosis factor ligand superfamily member 13
- Category：
- Approved Drugs：
2 Details
- Drugs in Clinical Trials：
30 Details
- Highest Development Stage：
Approved
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