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Cynomolgus CLEC4C / BDCA2 Protein, Fc Tag (MALS verified)

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Product Details

  • Synonym

    DLEC, CLEC4C, BDCA-2, CD303, CLECSF11, CLECSF7, HECL

  • Source

    Cynomolgus CLEC4C Protein, Fc Tag (CLC-C5253) is expressed from human 293 cells (HEK293). It contains AA Tyr 48 - Ile 212 (Accession # A0A2K5UWP4-1).

    Predicted N-terminus: Pro

    Request for sequence
  • Molecular Characterization

    CLEC4C Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the N-terminus.

    The protein has a calculated MW of 45.9 kDa. The protein migrates as 53-63 KDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    CLEC4C SDS-PAGE

    Cynomolgus CLEC4C Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    CLEC4C SEC-MALS

    The purity of Cynomolgus CLEC4C Protein, Fc Tag (Cat. No. CLC-C5253) is more than 90% and the molecular weight of this protein is around 95-120 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     CLEC4C ELISA

    Immobilized Cynomolgus CLEC4C Protein, Fc Tag (Cat. No. CLC-C5253) at 0.5 μg/mL (100 μL/well) can bind Litifilimab with a linear range of 0.1-2 ng/mL (QC tested).

    Protocol

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Background

CLEC4C (C-type lectin domain family 4 member C), also known as BDCA2, CLECSF11, CLECSF7, DLEC and CD303. Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cell. Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man. Binds to serum IgG. Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium.

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Drug Development Progress
  • English Name:

    C-Type lectin domain family 4 member C

  • Category:

  • Approved Drugs:

    0 Details

  • Drugs in Clinical Trials:

    9 Details

  • Highest Development Stage:

    Phase 3 Clinical

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