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CD39

CD39信息

英文名称:Ectonucleoside triphosphate diphosphohydrolase 1上市药物数量0
中文名称外核苷三磷酸二磷酸水解酶-1临床药物数量11
靶点别称CD39 Antigen，CD39，EC 3.6.1.5，NTPDase-1，NTPDase 1，ATPDase，SPG64，EC:3.6.1.5，Ecto-ATPase 1，Lymphoid cell activation antigen，ENTPD1，Ectonucleoside Triphosphate Diphosphohydrolase 1，Ecto-ATPDase 1，Ecto-Apyrase，Ecto-ATP diphosphohydrolase 1，EC 3.6.1最高研发阶段临床二期
英文名称:Ectonucleoside triphosphate diphosphohydrolase 1
中文名称外核苷三磷酸二磷酸水解酶-1
靶点别称CD39 Antigen，CD39，EC 3.6.1.5，NTPDase-1，NTPDase 1，ATPDase，SPG64，EC:3.6.1.5，Ecto-ATPase 1，Lymphoid cell activation antigen，ENTPD1，Ectonucleoside Triphosphate Diphosphohydrolase 1，Ecto-ATPDase 1，Ecto-Apyrase，Ecto-ATP diphosphohydrolase 1，EC 3.6.1
上市药物数量0
临床药物数量11
最高研发阶段Phase 2 Clinical

CD39产品列表

  • 属性

    Protein (8)

  • 产品库

    在线 (8)

  • 物种

    Human (6)Mouse (1)Cynomolgus (1)

  • 标签

    His Tag (5)His Tag & Avi Tag (2)Mouse IgG Fc Tag (1)

  • 标记

    Unconjugated (6)Biotin-labeled (2)

共 8 项数据
  • 1

CD39分子背景

CD39 is also known as Ectonucleoside triphosphate diphosphohydrolase 1, ENTPD1, NTPDase 1, Ecto-ATPDase 1, in the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. NTPDase-1 was originally described as CD39, a B lymphocyte cell surface marker, but it is also present on the surface of natural killer cells, T cells, and some endothelial cells.Regulatory T cells(Tregs) mediate immunosuppression through multiple, non-redundant, cell-contact dependent and independent mechanisms, a growing body of evidence suggests an important role for the CD39-CD73-adenosine pathway. CD39 ectonucleotidase is the rate-limiting enzyme of a cascade leading to the generation of suppressive adenosine that alters CD4 and CD8 T cell and natural killer cell antitumor activities.

CD39分子别名

CD39,ENTPD1,NTPDase 1,Entpd1,Ecto-ATPDase 1,Ecto-ATPase 1

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