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组分（Materials Provided）
Box A(2-8°C)IDComponentsSizeRIPO-RWM009K-C01Liver organoid Basal medium A9mlRIPO-RWM009K-C02Liver organoid Basal medium B9mlRIPO-RWM009K-C03Liver organoid Basal medium C13.5mlRIPO-RWM009K-C04Liver organoid Basal medium D22.5mlBox B(-20°C)IDComponentsSizeRIPO-RWM009K-1-C01Liver organoid Supplement A1mlRIPO-RWM009K-1-C02Liver organoid Supplement B1mlRIPO-RWM009K-1-C03Liver organoid Supplement C-11.2mlRIPO-RWM009K-1-C04Liver organoid Supplement C-20.3mlRIPO-RWM009K-1-C05Liver organoid Supplement D-12mlRIPO-RWM009K-1-C06Liver organoid Supplement D-20.5ml产品描述（Product Details）
Human iPSC-Derived Liver Organoid Differentiation Kit allows hESC or hiPSC to differentiate into liver organoids. Liver organoids are three-dimensional in vitro models with a cellular composition and structural organization that is representative to the human liver. This kit can produce 48 liver organoids in four steps.
产品特征（Product Specification）
The basic medium of this kit is a serum-free, well-defined medium with minimal batch variation to which differentiation factors are added. This medium does not contain antibiotics, the addition of which may affect organoid differentiation.
存储（Storage）
The unopened Box A is stable for 12 months from the date of manufacture if stored under 2-8°C.
The unopened Box B is stable for 12 months from the date of manufacture if stored under -20°C.
The opened kit should be stored according to components table.- *请注意，为了支持完整的类器官培养和维持过程，本产品必须与Human iPSC-Derived Liver Organoid Expansion and Maintenance Medium(Cat. No RIPO-RWM010）一起使用。您可以点击此链接获取产品信息。
质量管理控制体系（QMS）
产品展示
产品示意（Product Diagram）
Protocol Diagram of liver organoid differentiation.
Orgnaoid Histology
H&E Staining of liver organoid.
Marker Expression
The liver organoids show expression of hepatocytes (HFN4a), hepatobiliary tracts (CK19), Albumin (ALB) and vascular endothelial cell (CD31).
Pre-mature liver organoids show liver lobules-like structure.
Organoid Activity
Liver organoids show better performance than HepG2 cell line in terms of the expression of Albumin, CYP3A4, CYP1A2, CYP2C9, CYP7A1 and BSEP.
Liver organoid show response to Rifampicin treatment as indication by the increase fluorescence intensity of CYP3A4.
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