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Azide-labeled Mouse B7-H4 Protein, His Tag (MALS verified)

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Qty.
B74-M52H7-100ug
¥6560.00
B74-M52H7-500ug (250ug X 2)
¥26250.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    B7-H4,VTCN1,B7S1,B7h.5

  • 表达区间及表达系统(Source)

    Azide-labeled Mouse B7-H4 Protein, His Tag (B74-M52H7) is expressed from human 293 cells (HEK293). It contains AA Leu 25 - Gly 257 (Accession # Q7TSP5-1).

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    B7-H4 Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 40.3 kDa. The protein migrates as 55-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method.

  • 纯度(Purity)

    90% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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  • 电泳(SDS-PAGE)

    B7-H4 SDS-PAGE

    Azide-labeled Mouse B7-H4 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    B7-H4 SEC-MALS

    The purity of Azide-labeled Mouse B7-H4 Protein, His Tag (Cat. No. B74-M52H7) is more than 85% and the molecular weight of this protein is around 58-70 kDa verified by SEC-MALS.

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背景介绍

V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1 / B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation.

前沿进展

 
药物研发进展
  • 英文全称:

    V-set domain-containing T-cell activation inhibitor 1

  • 中文全称:

    含V区域T细胞激活抑制因子1

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    9 详情

  • 最高研发阶段:

    临床三期

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