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Mouse BCMA / TNFRSF17 Protein, His Tag

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BCA-M52H3-100ug
¥3675.00
BCA-M52H3-1mg
¥26250.00
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产品详情

  • 分子别名(Synonym)

    TNFRSF17,CD269,BCM,BCMA

  • 表达区间及表达系统(Source)

    Mouse BCMA, His Tag (BCA-M52H3) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Thr 49 (Accession # O88472-1).

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    BCMA Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 7.5 kDa. The protein migrates as 13 kDa and 14 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 偶联(Conjugate)

    Unconjugated

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method.

  • 纯度(Purity)

    95% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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  • 电泳(SDS-PAGE)

    BCMA SDS-PAGE

    Mouse BCMA, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • 活性(Bioactivity)-ELISA

     BCMA ELISA

    Immobilized Mouse BCMA, His Tag (Cat. No. BCA-M52H3) at 0.5 μg/mL (100 μL/well) can bind Mouse BAFF, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. BAF-M5257) with a linear range of 0.2-3 ng/mL (QC tested).

    Protocol
  •  BCMA ELISA

    Immobilized Mouse BCMA, His Tag (Cat. No. BCA-M52H3) at 2 μg/mL (100 μL/well) can bind Human BAFF, Fc Tag, active trimer (Cat. No. BAF-H5261) with a linear range of 0.2-6 ng/mL (Routinely tested).

    Protocol
  •  BCMA ELISA

    Immobilized Mouse BCMA, His Tag (Cat. No. BCA-M52H3) at 2 μg/mL (100 μL/well) can bind Human APRIL, Fc Tag with a linear range of 0.1-3 ng/mL (Routinely tested).

    Protocol

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背景介绍

Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) is also known as B-cell maturation protein (BCMA), CD antigen CD269, which is a member of the TNF-receptor superfamily. TNFRSF17 contains one TNFR-Cys repeat. TNFRSF17 is expressed in mature B-cells, but not in T-cells or monocytes. TNFRSF17 is receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. TNFRSF17 promotes B-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 can activate NF-kappa-B and JNK.

前沿进展

 
药物研发进展
  • 英文全称:

    B-cell maturation protein

  • 中文全称:

    B细胞成熟蛋白

  • 种类:

  • 上市药物数量:

    7 详情

  • 临床药物数量:

    117 详情

  • 最高研发阶段:

    临床三期

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