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Human CD3 delta Protein, His Tag

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CDD-H5224-100ug
¥3310.00
CDD-H5224-1mg
¥18480.00
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产品详情

  • 分子别名(Synonym)

    CD3D,CD3-DELTA,T3D

  • 表达区间及表达系统(Source)

    Human CD3 delta, His Tag (CDD-H5224) is expressed from human 293 cells (HEK293). It contains AA Phe 22 - Ala 105 (Accession # P04234-1).

    Predicted N-terminus: Phe 22

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    CD3 delta Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 11.4 kDa. The protein migrates as 18-28 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 偶联(Conjugate)

    Unconjugated

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method.

  • 纯度(Purity)

    >90% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

数据展示

  • 电泳(SDS-PAGE)

    CD3 delta SDS-PAGE

    Human CD3 delta, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

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背景介绍

T-cell surface glycoprotein CD3 delta, also known as CD3D. CD3D, together with CD3- epsilon(CD3E) , CD3-gamma and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z.

前沿进展

 
药物研发进展
  • 英文全称:

    T cell surface glycoprotein CD3

  • 中文全称:

    T细胞表面糖蛋白CD3复合体

  • 种类:

  • 上市药物数量:

    8 详情

  • 临床药物数量:

    177 详情

  • 最高研发阶段:

    临床二期

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