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PE-Labeled Human DLL3 Protein, His Tag (Site-specific conjugation)

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DL3-HP2H7-25tests
¥3520.00
DL3-HP2H7-200tests
¥21840.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    Delta3,delta-like 3 (Drosophila),delta-like protein 3,DLL3,Pudgy,SCDO1,SCDO1delta3

  • 表达区间及表达系统(Source)

    PE-Labeled Human DLL3 Protein, His Tag (DL3-HP2H7) is produced via site-specific conjugation of PE to Human DLL3 Protein, His Tag under optimal conditions with a proprietary technology. Human DLL3 Protein, His Tag is expressed from human 293 cells (HEK293). It contains AA Ala 27 - Leu 492 (Accession # Q9NYJ7-1).

    Predicted N-terminus: Ala 27

    Request for sequence

  • 蛋白结构(Molecular Characterization)

    DLL3 Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 52.1 kDa.

  • 偶联(Conjugate)

    PE

    Excitation Wavelength: 488 nm / 561 nm

    Emission Wavelength: 575 nm

  • 应用说明(Application)

    Please note that this product is NOT compatible to streptavidin detection system.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, 0.5% BSA, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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  • 活性(Bioactivity)-FACS

     DLL3 FACS

    5e5 of anti-DLL3 CAR-293 cells were stained with 100 μL of 1:25 dilution (4 μL stock solution in 100 μL FACS buffer) of PE-Labeled Human DLL3 Protein, His Tag (Cat. No. DL3-HP2H7) and negative control protein respectively. PE signal was used to evaluate the binding activity (QC tested).

    Protocol

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背景介绍

Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands.May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. DLL3 protein is expressed on the surface of tumor cells but not in normal adult tissues.

前沿进展

 
药物研发进展
  • 英文全称:

    Delta-like protein 3

  • 中文全称:

    δ样蛋白-3

  • 种类:

  • 上市药物数量:

    1 详情

  • 临床药物数量:

    17 详情

  • 最高研发阶段:

    批准上市

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