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Rhesus macaque EGF R Protein, Fc Tag (MALS verified)

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EGR-C5252-100ug
¥2625.00
EGR-C5252-1mg (500ug X 2)
¥15120.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    EGFR,ERBB,ERBB1,HER1,PIG61,mENA

  • 表达区间及表达系统(Source)

    Rhesus macaque EGF R, Fc Tag (EGR-C5252) is expressed from human 293 cells (HEK293). It contains AA Leu 25 - Ser 645 (Accession # P55245).

    Predicted N-terminus: Leu 25

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    EGF R Structure

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 95.3 kDa. The protein migrates as 116-120 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 偶联(Conjugate)

    Unconjugated

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method.

  • 纯度(Purity)

    95% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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  • 电泳(SDS-PAGE)

    EGF R SDS-PAGE

    Rhesus macaque EGF R, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • SEC-MALS

    EGF R SEC-MALS

    The purity of Rhesus macaque EGF R, Fc Tag (Cat. No. EGR-C5252) is more than 85% and the molecular weight of this protein is around 225-245 kDa verified by SEC-MALS.

    Report
  • 活性(Bioactivity)-ELISA

     EGF R ELISA

    Immobilized Human EGF, Tag Free at 10 μg/mL (100 μL/well) can bind Rhesus macaque EGF R, Fc Tag (Cat. No. EGR-C5252) with a linear range of 39-1250 ng/mL (QC tested).

    Protocol

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背景介绍

The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer.

前沿进展

 
药物研发进展
  • 英文全称:

    Epidermal growth factor receptor erbB1

  • 中文全称:

    表皮生长因子受体erbB1

  • 种类:

  • 上市药物数量:

    33 详情

  • 临床药物数量:

    182 详情

  • 最高研发阶段:

    批准上市

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