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Human FGF-21 Protein, His Tag

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FG1-H5243-100ug
¥2310.00
FG1-H5243-1mg
¥18900.00
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  • 分子别名(Synonym)

    FGF-21, FGF21

  • 表达区间及表达系统(Source)

    Human FGF-21, His Tag (FG1-H5243) is expressed from human 293 cells (HEK293). It contains AA His 29 - Ser 209 (Accession # Q9NSA1-1).

    Predicted N-terminus: His

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    FGF-21 Structure

    This protein carries a polyhistidine tag at the N-terminus.

    The protein has a calculated MW of 21.3 kDa. The protein migrates as 25-28 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 偶联(Conjugate)

    Unconjugated

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method.

  • 纯度(Purity)

    90% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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  • 电泳(SDS-PAGE)

    FGF-21 SDS-PAGE

    Human FGF-21, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

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背景介绍

Fibroblast growth factor 21 (FGF21), which stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression. FGF21 has been shown to protect animals from diet-induced obesity when overexpressed in transgenic mice. It also lowers blood glucose and triglyceride levels when administered to diabetic rodents, suggesting it may exhibit the therapeutic characteristics necessary for effective treatment of diabetes. Treatment of animals with FGF21 results in increased energy expenditure, fat utilisation and lipid excretion. FGF21 is most abundantly expressed in the liver, and also expressed in the thymus at lower levels.

前沿进展

 
药物研发进展
  • 英文全称:

    Fibroblast growth factor 21

  • 中文全称:

    成纤维细胞生长因子-21

  • 种类:

  • 上市药物数量:

    0 详情

  • 临床药物数量:

    9 详情

  • 最高研发阶段:

    临床三期

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