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Cynomolgus IL-11 Protein, His Tag

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IL1-C5243-100ug
¥3675.00
IL1-C5243-1mg
¥24255.00
合计0件 产品金额¥ 0

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  • 分子别名(Synonym)

    IL-11,Interleukin-11,AGIF,Oprelvekin,IL11

  • 表达区间及表达系统(Source)

    Cynomolgus IL-11 Protein, His Tag (IL1-C5243) is expressed from human 293 cells (HEK293). It contains AA Pro 22 - Leu 199 (Accession # P20808).

    Predicted N-terminus: His

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    IL-11 Structure

    This protein carries a polyhistidine tag at the N-terminus.

    The protein has a calculated MW of 21.3 kDa. The protein migrates as 22-26 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • 偶联(Conjugate)

    Unconjugated

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method.

  • 纯度(Purity)

    90% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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  • 电泳(SDS-PAGE)

    IL-11 SDS-PAGE

    Cynomolgus IL-11 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • 活性(Bioactivity)-ELISA

     IL-11 ELISA

    Immobilized Biotinylated Human IL-11 R alpha, Fc,Avitag (Cat. No. ILR-H82F5) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Cynomolgus IL-11 Protein, His Tag (Cat. No. IL1-C5243) with a linear range of 5-156 ng/mL (QC tested).

    Protocol

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背景介绍

Interleukin-11 (IL-11) is a pleiotropic cytokine that stimulates megakaryocytopoiesis, resulting in increased production of platelets, as well as activating osteoclasts, inhibiting epithelial cell proliferation and apoptosis, and inhibiting macrophage mediator production. These functions may be particularly important in mediating the hematopoietic, osseous and mucosal protective effects of IL-11. The cytokine also possesses anti-inflammatory activity, and has been proposed as a therapeutic agent in the treatment of chronic inflammatory diseases, such as Crohn's disease and rheumatoid arthritis. Although IL-11 was initially believed to be restricted to mammals, subsequent studies demonstrated it to be expressed in fish. Despite close similarity in gene structure and conservation of key amino acids between fish and mammalian IL-11, they share relatively low overall amino acid identity and may not necessarily be functionally analogous.

前沿进展

 
药物研发进展
  • 英文全称:

    Interleukin-11

  • 中文全称:

    白介素11

  • 种类:

  • 上市药物数量:

    1 详情

  • 临床药物数量:

    3 详情

  • 最高研发阶段:

    批准上市

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