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PE-Labeled Human IL-3 R alpha / CD123 Protein, His Tag (Site-specific conjugation)

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货号-规格
价格
Qty.
ILA-HP2H8-25tests
¥3675.00
ILA-HP2H8-200tests
¥22890.00
合计0件 产品金额¥ 0

产品详情

  • 分子别名(Synonym)

    IL3R,IL3RA,IL-3Ra,IL-3R-alpha,IL3RAY,IL3RX,IL3RY,CD123 antigen,CD123,hIL3Ra,hIL-3Ra,MGC34174,IL-3 R alpha

  • 表达区间及表达系统(Source)

    PE-Labeled Human IL-3 R alpha, His Tag (ILA-HP2H8) is produced via site-specific conjugation of PE to Human IL-3 R alpha, His Tag under optimal conditions with a proprietary technology. Human IL-3 R alpha, His Tag is expressed from human 293 cells (HEK293). It contains AA Thr 19 - Arg 305  (Accession # P26951-1).

    Predicted N-terminus: Thr 19

    Request for sequence

  • 蛋白结构(Molecular Characterization)

    IL-3 R alpha Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 36.7 kDa.

  • 偶联(Conjugate)

    PE

    Excitation Wavelength: 488 nm / 561 nm

    Emission Wavelength: 575 nm

  • 应用说明(Application)

    Please note that this product is NOT compatible to streptavidin detection system.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in PBS, 0.5% BSA, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

数据展示

  • 活性(Bioactivity)-FACS

     IL-3 R alpha FACS

    5e5 of anti-IL-3 R alpha CAR-293 cells were stained with 100 μL of 1:25 dilution (4 μL stock solution in 100 μL FACS buffer) of PE-Labeled Human IL-3 R alpha, His Tag (Cat. No. ILA-HP2H8) and negative control protein respectively. PE signal was used to evaluate the binding activity (QC tested).

    Protocol

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背景介绍

Interleukin 3 receptor alpha (low affinity) (IL3RA), also known as CD123 (Cluster of Differentiation 123) is a 70-kD glycoprotein member of the hematopoietin receptor superfamily. This protein associates with a beta subunit common to the receptors for IL-5 and granulocyte-macrophage colony-stimulating factor (GM-CSF) to form a high-affinity receptor for IL-3. The interleukin-3 receptor α chain (CD123) has been identified as a potential immunotherapeutic target because it is overexpressed in AML compared with normal hematopoietic stem cells.

前沿进展

 
药物研发进展
  • 英文全称:

    Interleukin-3 receptor subunit alpha

  • 中文全称:

    白细胞介素-3受体α亚基

  • 种类:

  • 上市药物数量:

    1 详情

  • 临床药物数量:

    37 详情

  • 最高研发阶段:

    批准上市

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