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Cynomolgus Integrin alpha 11 beta 1 (ITGA1&ITGB1) Heterodimer Protein, His Tag&Tag Free

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IT1-C53W3-100ug
¥4305.00
IT1-C53W3-1mg (500ug X 2)
¥30240.00
合计0件 产品金额¥ 0

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  • 分子别名(Synonym)

    Integrin alpha 11 beta 1,ITGA11&ITGB1

  • 表达区间及表达系统(Source)

    Cynomolgus ITGA1&ITGB1 Heterodimer Protein, His Tag&Tag Free (IT1-C53W3) is expressed from CHO cells. It contains AA Phe 23 - Pro 1131 & Gln 21 – Asp 728 (Accession # A0A2K5U8X4-1 & XP_005564990.1).

    Predicted N-terminus: Phe 23 & Gln 21

    Request for sequence
  • 蛋白结构(Molecular Characterization)

    Integrin alpha 11 beta 1 Structure

    Cynomolgus ITGA1&ITGB1 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA1 and ITGB1, has a calculated MW of 131.4 kDa (ITGA1) and 83.6 kDa (ITGB1). Subunit ITGA1 is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB1 contains no tag but a basic tail at the C-terminus. The protein migrates as 105-115 kDa and >170 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.

  • 偶联(Conjugate)

    Unconjugated

  • 内毒素(Endotoxin)

    Less than 1.0 EU per μg by the LAL method.

  • 纯度(Purity)

    90% as determined by SDS-PAGE.

  • 制剂(Formulation)

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法(Reconstitution)

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储(Storage)

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • 质量管理控制体系(QMS)

    1. 质量管理体系(ISO, GMP)
    2. 质量优势
    3. 质控流程

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  • 电泳(SDS-PAGE)

    Integrin alpha 11 beta 1 SDS-PAGE

    Cynomolgus ITGA1&ITGB1 Heterodimer Protein, His Tag&Tag Free on SDS-PAGE under non-reducing (NR) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%undefined.

  • 活性(Bioactivity)-ELISA

     Integrin alpha 11 beta 1 ELISA

    Immobilized Native Human Collagen IV Protein at 10 μg/mL (100 μL/well) can bind Cynomolgus ITGA1&ITGB1 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT1-C53W3) with a linear range of 0.156-1.25 μg/mL (QC tested).

    Protocol

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背景介绍

Integrin alpha-1/beta-1 is a receptor for laminin and collagen. The Integrin alpha-1/beta-1 and Integrin alpha-2/beta-1 integrins provide critical support for vascular endothelial growth factor signaling, endothelial cell migration, and tumor angiogenesis. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.

前沿进展

 
药物研发进展
  • 英文全称:

    Leukocyte adhesion glycoprotein LFA-1 alpha

  • 中文全称:

    白细胞粘附糖蛋白LFA-1α

  • 种类:

  • 上市药物数量:

    1 详情

  • 临床药物数量:

    2 详情

  • 最高研发阶段:

    批准上市

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